AI Article Synopsis
- There is a lack of integrated databases for Traditional Korean Medicine (TKM) that support drug discovery, which led to the creation of PharmDB-K.
- PharmDB-K provides extensive data on TKM-related drugs, disease indications, and protein interactions, built from numerous sources including databases, Pharmacopoeias, and literature.
- The database currently holds detailed information on 262 TKM products, over 7,800 drugs, 3,700 diseases, and also features specialized tools like phExplorer and BioMart for efficient navigation and analysis of the TKM network.
Article Abstract
Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-associated drugs (compound), disease indication, and protein relationships. To explore the underlying molecular interaction of TKM, we integrated fourteen different databases, six Pharmacopoeias, and literature, and established a massive bio-pharmacological network for TKM and experimentally validated some cases predicted from the PharmDB-K analyses. Currently, PharmDB-K contains information about 262 TKMs, 7,815 drugs, 3,721 diseases, 32,373 proteins, and 1,887 side effects. One of the unique sets of information in PharmDB-K includes 400 indicator compounds used for standardization of herbal medicine. Furthermore, we are operating PharmDB-K via phExplorer (a network visualization software) and BioMart (a data federation framework) for convenient search and analysis of the TKM network. Database URL: http://pharmdb-k.org, http://biomart.i-pharm.org.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640719 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142624 | PLOS |
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