AI Article Synopsis
- The study highlights the lack of data on pain-related genetic variations in patients with sickle cell disease (SCD), particularly among African-Americans.
- Researchers analyzed genotype and allele frequencies of 115 SNPs in a group of 199 African-American patients with SCD, finding differences compared to existing public database data.
- This research aims to improve pain management in SCD patients by establishing a reference for future genetic studies, promoting personalized pain treatment approaches.
Article Abstract
Background: Prospective pain genetics research is hindered by a lack of data on the prevalence of polymorphisms in pain-relevant genes for patients with sickle cell disease (SCD). For African-Americans in general, limited information is available in public databases.
Methods: We prioritized and examined the genotype and allele frequencies of 115 SNPs from 49 candidate pain genes in 199 adult African-Americans and pediatric patients of African origin with SCD. Analyses were performed and compared with available data from public databases.
Results: Genotype and allele frequencies of a number of SNPs were found to be different between our cohort and those from the databases and between adult and pediatric subjects.
Conclusion: As pain therapy is inadequate in a significant percentage of patients with SCD, candidate pain genetic studies may aid in designing precision pain medicine. We provide prevalence data as a reference for prospective genetic studies in this population.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909047 | PMC |
| http://dx.doi.org/10.2217/pgs.15.126 | DOI Listing |
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