This article presents a method that enables the generation rate from one or /more particle sources to be estimated, using far-field concentration measurements. The method is made up of two distinct steps; a calibration phase, followed by an estimation phase. The calibration phase makes it possible to create a transfer relationship between a known source ("reference source") and the measurement of the far-field concentration. The second step consists of estimating unknown source generation rates by inverting the transfer relationship and using measurements of far-field concentrations resulting from these unknown sources. In addition, this article presents a technique to improve the positioning of the sensors in the room in which the sources are situated. A numerical study using computational fluid dynamics was first conducted to theoretically validate the estimation method and assist with choosing the sensor positions in the experimental rig. The study established that, with ideal sensors, the difference between the real and estimated generation rates can be accurate to within 0.1%. The method was then deployed on an experimental case. The results confirmed that it is possible to estimate an isolated source. However, the quality of the estimation deteriorated when the source to be estimated was significantly different from the reference source, from an aerodynamic perspective.
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http://dx.doi.org/10.1080/15459624.2015.1101120 | DOI Listing |
Pediatr Cardiol
January 2025
Pediatric Heart Center, Johann-Wolfgang-Goethe University Clinic, Theodor-Storm-Kai 7, 60596, Frankfurt, Germany.
This proposal presents a proof of concept for the use of pulmonary flow restrictors (PFRs) based on MVP™-devices, drawing from clinical experience, and explores their potential role in the management of newborns with hypoplastic left heart syndrome (HLHS), other complex left heart lesions, and infants with end-stage dilated cardiomyopathy (DCM). At this early stage of age, manually adjusted PFRs can be tailored to patient's size and hemodynamic needs. Although currently used off-label, PFRs have substantial potential to improve outcomes in these vulnerable patient populations.
View Article and Find Full Text PDFEcotoxicology
January 2025
Ecotoxicology Research group, School of Science, RMIT University, Melbourne, VIC, Australia.
Pharmaceuticals, including non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (IBU) and naproxen (NPX), are widely used for medical purposes but have also become prevalent environmental contaminants. However, there is limited understanding of their effects on aquatic organisms, especially regarding multigenerational and mixture exposures. This study aimed to evaluate the toxicological impacts of ibuprofen and naproxen, individually and in combination, on three generations of Daphnia carinata, a freshwater organism.
View Article and Find Full Text PDFEur J Epidemiol
January 2025
Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.
The Stockholm Early Detection of Cancer Study (STEADY-CAN) cohort was established to investigate strategies for early cancer detection in a population-based context within Stockholm County, the capital region of Sweden. Utilising real-world data to explore cancer-related healthcare patterns and outcomes, the cohort links extensive clinical and laboratory data from both inpatient and outpatient care in the region. The dataset includes demographic information, detailed diagnostic codes, laboratory results, prescribed medications, and healthcare utilisation data.
View Article and Find Full Text PDFCytotherapy
December 2024
Department of Medicine, Kuopio University Hospital, Kuopio, Finland. Electronic address:
The amount of CD34 cells has been for decades the most important marker of autologous graft quality, but other graft cells, including various lymphocyte subsets, have gained some interest. This review attempts to summarize what is known about autograft cellular composition regarding post-transplant outcomes. The amount of CD34 cells in the graft is associated with tempo of platelet recovery.
View Article and Find Full Text PDFCytotherapy
November 2024
Institute of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK. Electronic address:
Background Aims: Extracellular vesicles (EVs) have gained traction as potential cell-free therapeutic candidates. Development of purification methods that are scalable and robust is a major focus of EV research. Yet there is still little in the literature that evaluates purification methods against potency of the EV product.
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