The study was aimed at tracking the proteomic profile of urine in 8 normal volunteers to 5-day dry immersion (DI). The proteome composition was determined by chromatography-mass spectrometry on high-efficient on-line liquid nano chromatograph Agilent 1100; complementary information about the protein spectra was obtained by dint of mass-spectrometer MaXis Impact 4G and hybrid mass-spectrometer LTQ-FT. Functional associations between proteins and biological functions were analyzed using computer system ANDCell (Associative Networks Discovery in Cells). A total of 256 proteins were identified; for 43 proteins difference in the detection rate during the baseline data collection and on DI day 4 exceeded 20%.
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Clin Chem Lab Med
January 2025
X-Pertise Consulting, Mittelhausbergen, France.
The presence of letrozole, an aromatase inhibitor, in an athlete's sample constitutes one of the more frequent anti-doping rules violation. It is possible to challenge this violation but it is the athletes who have to demonstrate their innocence. The conditions to evidence/establish the absence of fault or negligence hinge on two points: 1.
View Article and Find Full Text PDFSci Rep
January 2025
Affiliated Mental Health Centre & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310013, China.
The tryptophan (TRP)-kynurenine (KYN) pathway is involved in the pathogenesis of schizophrenia. This study aimed to investigate the levels of TRP-KYN metabolites in serum and urine of patients with first-episode schizophrenia (FES) and their association with clinical manifestations. This study included 38 drug-naive patients with FES and 43 healthy controls (HCs).
View Article and Find Full Text PDFUrology
January 2025
Division of Urologic Oncology, Cancer Treatment and Research Center (CTIC) Luis Carlos Sarmiento Angulo Foundation, Bogotá, Colombia. Electronic address:
J Tradit Complement Med
January 2025
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan.
The medicinal value of herbal products is often rooted in their "traditional" use, recontextualized by modern biomedical research granting them certain medical uses. L. (Asteraceae), native to Mexico, exemplifies such historical developments of a species that played a key role in developing a major pharmacologically active compound - lutein.
View Article and Find Full Text PDFJMIR Form Res
January 2025
Klick Applied Sciences, Klick Health, Toronto, ON, Canada.
Background: Identifying subtle changes in the menstrual cycle is crucial for effective fertility tracking and understanding reproductive health.
Objective: The aim of the study is to explore how fundamental frequency features vary between menstrual phases using daily voice recordings.
Methods: This study analyzed smartphone-collected voice recordings from 16 naturally cycling female participants, collected every day for 1 full menstrual cycle.
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