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Cystatin C is associated with osteoporosis and fractures: An observational study based on Mendelian randomization analysis.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Research for Genetic Epidemiology and Genomics, School of Public Health, Suzhou Medical College of Soochow University, Suzhou Jiangsu 215123, China.
Objectives: Osteoporosis is characterized by decreased bone mass and damaged bone microstructure, often leading to fragility fractures. Low bone mineral density is a key risk factor for fractures. Serum cystatin C (CysC), an endogenous marker of glomerular filtration rate, is negatively correlated with bone mineral density and may be a potential risk factor for osteoporosis.
View Article and Find Full Text PDFInterferons and Cytokines Induce Transcriptional Activation of the Long-Interspersed Element-1 in Myeloid Cells from Autoimmune Patients.
Eur J Immunol
March 2025
Division of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Approximately 17% of our genome consists of copies of the retrotransposon "long interspersed element-1" (LINE-1 or L1). Patients with systemic lupus erythematosus (SLE) frequently have autoantibodies against the L1-encoded ORF1 protein (ORF1p), which correlate with disease activity and interferon gene signature. ORF1p is present in neutrophils from patients with active disease in perinuclear ribonucleoprotein particles that also contain Ro60 and nucleic acid sensors.
View Article and Find Full Text PDFAssociations of HLA-DRB1 shared epitope alleles with cardiovascular disease and events in a multi-ethnic community-living population: The multi-ethnic study of atherosclerosis (MESA).
Hum Immunol
March 2025
Department of Orthopaedic Surgery, University of California, San Diego, United States. Electronic address:
Objective: Rheumatoid arthritis (RA) has been considered an independent risk factor for cardiovascular disease (CVD), where RA and CVD later manifest following genetic predisposition and an extended preclinical phase.TheHLA-DRB1Shared Epitope (SE)allelespredispose for RA andare associated withhigherrisk of CV mortality in RA patients, but have not been evaluated in a community-living population.Thus, we evaluated whetherHLA-DRB1 (SE) alleleswereassociated with subclinical CVD, CV events, and mortality in the Multi-Ethnic Study of Atherosclerosis (MESA).
View Article and Find Full Text PDFThe relationship between connective tissue disease and autoantibody positivity in pneumoconiosis cases.
Medicine (Baltimore)
March 2025
Occupational Diseases Clinic, Eskişehir City Hospital, Eskişehir, Turkey.
This correlation has been studied since the 1930s, and it is believed that exposure to silica can lead to various autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and systemic sclerosis. The exact mechanisms behind this link remain unclear. This study aimed to evaluate the prevalence of connective tissue diseases (CTD) and positive autoantibodies in pneumoconiosis patients and the association between radiological categorization and autoantibodies.
View Article and Find Full Text PDFAssessing causality between mitochondrial-associated proteins with musculoskeletal diseases: A Mendelian randomization study.
Medicine (Baltimore)
March 2025
Department of Orthopedics, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.
Musculoskeletal diseases are the leading cause of disability-adjusted life years. Mitochondria, often referred to as the "powerhouses" of cells, are believed to play a role in regulating cellular metabolism and differentiation, potentially influencing the occurrence and progression of musculoskeletal diseases. However, the exact causal relationships remain to be defined.
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