The CRISPR-Cas9 system is frequently used to create small deletions in the genomes of mammalian cells, but the isolation of precisely targeted mutants is still challenging. A new, two-step 'pop in & out' targeting approach facilitates this task.
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| http://dx.doi.org/10.1186/s13059-015-0810-2 | DOI Listing |
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Using "pop-up" clinics and live-attenuated influenza vaccine to reduce barriers to flu vaccination among college students.
J Am Coll Health
January 2025
Pediatric Infectious Diseases, Anne & Robert Lurie Children's Hospital, Chicago, IL, USA.
College students have cited inconvenience, ease of forgetting, and lack of time as barriers to influenza (flu) vaccine receipt. We hypothesized that "pop-up" clinics and live-attenuated influenza vaccine (LAIV) would facilitate delivery and align with preferences of college students. During the 2023-2024 flu season, undergraduate participants were recruited to receive LAIV at 5 "pop-up" clinics across a large midwestern campus.
View Article and Find Full Text PDFEnhancing Medical Student Engagement Through Cinematic Clinical Narratives: Multimodal Generative AI-Based Mixed Methods Study.
JMIR Med Educ
January 2025
Department of Medical Education, University of Idaho, 875 Perimeter Drive MS 4061, WWAMI Medical Education, Moscow, ID, 83844-9803, United States, 1 5092090908.
Background: Medical students often struggle to engage with and retain complex pharmacology topics during their preclinical education. Traditional teaching methods can lead to passive learning and poor long-term retention of critical concepts.
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Analysis and Categorization of Various Types of Vocal Distortion in Rock, Metal, Pop Styles, and Throat Singing Observed by High-Speed Digital Imaging.
J Voice
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Faculty of Design, Kyushu University, 4-9-1 Shiobaru, Minami-ku, Fukuoka 815-8540, Japan.
Introduction: Vocal distortion, also known as a scream or growl, is used worldwide as an essential technique in singing, especially in rock and metal, and as an ethnic voice in Mongolian singing. However, the production mechanism of vocal distortion is not yet clearly understood owing to limited research on the behavior of the larynx, which is the source of the distorted voice.
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Use of vaginal pessary in women with symptomatic pelvic organ prolapse: Risk factors for failure one year after insertion.
Eur J Obstet Gynecol Reprod Biol
December 2024
Department of Obstetrics and Gynaecology, Caen University Hospital, Caen, France; Inserm U1086 "ANTICIPE", Unité de Recherche Interdisciplinaire pour la Prévention et le Traitement des Cancers, Caen, France.
Introduction: Vaginal pessaries are offered as a first-line treatment for symptoms associated with pelvic organ prolapse (POP). The objective of our study was to identify risk factors for failure of pessary use within 1 year of insertion.
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Frailty and pelvic organ prolapse: Colpocleisis with or without hysterectomy as a treatment modality in elderly patients.
Eur J Obstet Gynecol Reprod Biol
December 2024
Ruth and Bruce Rappaport, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel; Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
Introduction: The rising prevalence of pelvic organ prolapse (POP) in the aging population underscores the need to reevaluate treatment options. This study examines obliterative procedures, specifically colpocleisis performed with (CH) and without (C) concomitant vaginal hysterectomy, as management strategies for frail, non-sexually active elderly patients with advanced prolapse.
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