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Cannabigerol Mitigates Haloperidol-Induced Vacuous Chewing Movements in Mice.
Neurotox Res
December 2024
Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Chronic use of typical antipsychotics can lead to varying motor effects depending on the timing of analysis. Acute treatment typically induces hypokinesia, resembling parkinsonism, while repeated use can result in tardive dyskinesia, a hyperkinetic syndrome marked by involuntary orofacial movements, such as vacuous chewing movements in mice. Tardive dyskinesia is particularly concerning due to its potential irreversibility and associated motor discomfort.
View Article and Find Full Text PDFEffects of oxotremorine on convulsions in mice induced by scopolamine and food intake after fasting.
Behav Brain Res
December 2024
Department of Medical Pharmacology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address:
Antimuscarinic administration and food intake cause convulsions in mice and rats after fasting for 48 h or less. Increased M and M muscarinic receptor expression in brain regions during fasting, and reversal of changes by refeeding may contribute to these seizures. Since receptor expression is regulated in response to agonist stimulation, this study investigated effects of nonselective muscarinic receptor agonist oxotremorine on convulsions in fasted animals.
View Article and Find Full Text PDFCaregiver-reported increased food motivation and adiposity in dogs receiving antiseizure drugs.
Vet Rec
December 2024
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Background: Idiopathic epilepsy is the most common chronic neurological disease in dogs and requires lifelong administration of antiseizure drugs (ASD). A decreased level of energy and increased food intake and weight gain have been described as long-lasting side effects.
Methods: We assessed food motivation (FM), using the previously validated dog obesity risk assessment questionnaire, in dogs diagnosed with idiopathic epilepsy (n = 222) and healthy dogs (n = 7086) to determine if epilepsy and ASD were associated with increased FM and adiposity and decreased activity.
Measuring the effects of ketogenic diet on neuropsychiatric disorder: A scoping review.
Prog Neuropsychopharmacol Biol Psychiatry
November 2024
Psychiatry Department, Texas Tech University Health Sciences Center, 3601 4th Street STOP 8103, Lubbock, TX 79430-8103, USA. Electronic address:
Article Synopsis
- The scoping review investigates the ketogenic diet's potential effectiveness as a treatment for various neuropsychiatric disorders, noting that while there is interest, the overall effectiveness is still uncertain.
- It considers a range of study types, including randomized controlled trials and observational studies, that follow DSM-5 guidelines for neuropsychiatric conditions.
- The review analyzes 30 studies that suggest the ketogenic diet could improve symptoms in disorders like Autism, ADHD, depression, and anxiety, but highlights the need for more thorough research to validate its use as a standard treatment.
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