This study investigated the mediation role played by children's executive function in the relationship between exposure to mild maternal depressive symptoms and problem behaviors. At ages 2, 3, and 6years, 143 children completed executive function tasks and a verbal ability test. Mothers completed the Beck Depression Inventory at each time-point, and teachers completed the Strengths and Difficulties Questionnaire at child age 6. Longitudinal autoregressive mediation models showed a mediation effect that was significant and quite specific; executive function (and not verbal ability) at age 3 mediated the path between mothers' depressive symptoms (but not general social disadvantage) at the first time-point and children's externalizing and internalizing problems at age 6. Improving children's executive functioning might protect them against the adverse effects of exposure to maternal depressive symptoms.
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http://dx.doi.org/10.1016/j.jecp.2015.09.022 | DOI Listing |
Nat Rev Dis Primers
January 2025
Division of Nephrology, Department of Medicine IV, Hospital of the Ludwig-Maximilians University, Munich, Germany.
Chronic kidney disease (CKD) is defined by persistent abnormalities of kidney function or structure that have consequences for the health. A progressive decline of excretory kidney function has effects on body homeostasis. CKD is tightly associated with accelerated cardiovascular disease and severe infections, and with premature death.
View Article and Find Full Text PDFJ Nucl Med
January 2025
Department of Nuclear Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Cognitive flexibility is the ability to appropriately adapt one's thinking and behavior to changing environmental demands and is conceptualized as an aspect of executive function. The dopamine system has been implicated in cognitive flexibility; however, a direct, that is, neurochemical, link to cognitive flexibility has not been shown yet. The aim of this study was, therefore, to investigate how cognitive flexibility is mediated by dopaminergic signaling in the ventromedial prefrontal cortex (vmPFC).
View Article and Find Full Text PDFJ Am Med Dir Assoc
January 2025
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Objectives: This study aimed to investigate the association between relative hypothermia measured by a wearable device and cognitive function, and to clarify whether relative hypothermia is a useful indicator for preventing poor cognitive function.
Design: Cross-sectional study.
Setting And Participants: The study included 103 community-dwelling older adults aged 60 to 90 years.
In 2021, a year before ChatGPT took the world by storm amid the excitement about generative artificial intelligence (AI), AlphaFold 2 cracked the 50-year-old protein-folding problem, predicting three-dimensional (3D) structures for more than 200 million proteins from their amino acid sequences. This accomplishment was a precursor to an unprecedented burgeoning of large language models (LLMs) in the life sciences. That was just the beginning.
View Article and Find Full Text PDFPsychol Bull
January 2025
Department of Kinesiology, University of North Carolina at Greensboro.
This meta-review provides the first meta-analytic evidence from published meta-analyses examining the effectiveness of acute exercise interventions on cognitive function. A multilevel meta-analysis with a random-effects model and tests of moderators were performed in R. Thirty systematic reviews with meta-analyses (383 unique studies with 18,347 participants) were identified.
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