AI Article Synopsis
- Strongly solvatochromic fluorophores with alkyl chains form bright fluorescent organic nanoparticles (FONs) in water, exhibiting significant fluorescence properties.
- The hydrophobic environment around the fluorophores leads to noticeable emission color changes when they are in different states (assembled vs. disassembled).
- The study shows that while monocytes/macrophages break down these FONs into green-yellowish vesicles, cancer cells retain the nanoparticles longer, and both cell types show no significant toxicity, indicating their potential as safe bioimaging agents.
Article Abstract
Strongly solvatochromic fluorophores are devised, containing alkyl chains and enable to self-assemble as very bright fluorescent organic nanoparticles (FONs) in water (Φf = 0.28). The alkyl chains impart each fluorophore with strongly hydrophobic surroundings, causing distinct emission colors between FONs where the fluorophores are associated, and their disassembled state. Such color change is harnessed to assess the long-term fate of FONs in both cancer cells and monocytes/macrophages. Disintegration of the orange-emitting FONs by monocytes/macrophages is evidenced through the formation of micrometer green-yellowish emitting vesicles. By contrast, cancer cells retain longer the integrity of organic nanoparticles. In both cases, no significant toxicity is detected, making FONs as valuable bioimaging agents for cell tracking with weak risks of deleterious accumulation and low degradation rate.
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| http://dx.doi.org/10.1002/adhm.201500562 | DOI Listing |
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