AI Article Synopsis
- Lipofuscin granules (LGs), known as "age pigments," accumulate in cells and vary in size and number across different brain regions.
- A study using Sudan Black dye on the temporal cortex of epileptic individuals aged 20 to 55 revealed that LGs grow larger with age but do not increase in number.
- The increase in the area of LGs may indicate changes in neuronal metabolism related to aging and potentially influenced by pathological conditions.
Article Abstract
Lipofuscin granules (LGs), the "age pigments", are autofluorescent cell products from lysosomes that diverge in number and size among brain regions. Human temporal cortex from 20- to 55-year-old epileptic subjects were studied with the fat soluble dye Sudan Black, under confocal and electron microscopy. Ultrastructural analysis showed that with age LGs increase in area, but not in number. Proportionally to the LGs area, the electron lucid portion increases and the electron dense reduces over time. The robust increase in lipid components is possibly due to modifications in the neuronal metabolism with age in physiological and pathological conditions.
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| http://dx.doi.org/10.3109/01913123.2015.1043416 | DOI Listing |
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