AI Article Synopsis
- A new compound called cerebroside E was found in the fruiting bodies of a mushroom species (Hericium erinaceus) and its structure was determined using various advanced scientific techniques.
- This compound was tested for medicinal purposes and showed promise in protecting kidney cells from damage caused by cisplatin, a common chemotherapy drug.
- Cerebroside E also demonstrated a notable ability to inhibit the formation of new blood vessels, which is significant for cancer treatment.
Article Abstract
A new cerebroside, cerebroside E (1) was isolated from the fruiting bodies of Hericium erinaceus (Hericiaceae). The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HR-MS, and chemical reactions. Compound 1 was evaluated for its applicability to medicinal use in several human diseases using cell-based assays. As a result, compound 1 attenuated cisplatin-induced nephrotoxicity in LLC-PK1 cells and exhibited a significant inhibitory effect on angiogenesis in HUVECs. These results collectively reflect the beneficial effects of compound 1 in cancer treatment.
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| http://dx.doi.org/10.1016/j.bmcl.2015.10.092 | DOI Listing |
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