Objective: To investigate the effect of closed vacuum drainage combined with heparin irrigation in the treatment of scald burns with seawater immersion in rabbits.
Methods: Twenty New Zealand rabbits were subjected to deep partial-thickness scald burns in 4 regions on the bilateral skin of the spine. The wounds were managed with common dressing (group A), common dressing after seawater immersion (group B), closed vacuum drainage after seawater immersion (group C), or closed vacuum drainage combined with heparin irrigation after seawater immersion (group D). Wound effusion and tissue necrosis were observed at 1, 3, 5 and 7 days after the burns. Tissue samples were collected from the wounds for HE staining and immunohistochemistry for VEGF and CD31, and the changes of capillary endothelial cells in the wound were observed using electron microscopy. The water content in the wound tissues was determined, and the wound healing rate was calculated after the injury.
Results: Sea water immersion of the wound results in earlier onset of edema and more extensive tissue necrosis in the scalded rabbits. The mean necrotic area in groups C and D was smaller than that in group B early after the burns, and vacuum drainage promoted necrotic tissue elimination and accelerated wound healing. Early after the burns, water content in the tissues increased with time in all the groups and reached the highest level at 3 days, and was significantly lower in groups C and D than in group B. Pathologically, vascular endothelial cell damage at the wound site was worsened after seawater immersion. In group D, the basement membrane damage was milder and the endothelial cell membrane remained intact at the wound site, where new blood vessels occurred at 3 days after the burns, a time earlier than that in the other 3 groups with also the highest vascular density.
Conclusions: Closed vacuum drainage combined with heparin irrigation can relieve edema at the scald wound with seawater immersion, improve microcirculation, accelerate the removal of necrotic tissue, and promote the growth of new blood vessels.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Photothermal Self-Healing Black g-CN Nanosheet-Based Coatings: A Novel Approach for Enhanced Anticorrosion and Antibiofouling Protection.
Small
January 2025
School of Material Science and Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, 212003, P. R. China.
Multifunctional coatings have great application value in the protection of Marine equipment, ships and ship facilities, but they still suffer from the disadvantages of high preparation cost and complicated synthesis methods. Herein, employing a simple method to synthesize black carbon nitride (BCN), as the filler in polydimethylsiloxane (PDMS) to construct BCN/PDMS composite coating with a multifunctional anti-corrosion/antifouling coating capable of photothermal self-healing property. Experimental results exhibit that the BCN/PDMS coating can still possesses excellent corrosion resistance after 28 d of immersion in the simulated seawater, and the impedance modulus still manages to reach 6.
View Article and Find Full Text PDFElevation of spectral components of electrodermal activity precedes central nervous system oxygen toxicity symptoms in divers.
Commun Med (Lond)
December 2024
Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Background: Oxygen-rich breathing mixtures up to 100% are used in some underwater diving operations for several reasons. Breathing elevated oxygen partial pressures (PO) increases the risk of developing central nervous system oxygen toxicity (CNS-OT) which could impair performance or result in a seizure and subsequent drowning. We aimed to study the dynamics of the electrodermal activity (EDA) and heart rate (HR) while breathing elevated PO in the hyperbaric environment (HBO) as a possible means to predict impending CNS-OT.
View Article and Find Full Text PDFDurable Antibacterial Photothermal Membrane Using Melanin-Inspired Cu-Doped Polynorepinephrine for Water Remediation.
Nano Lett
December 2024
Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Solar-driven interfacial evaporation is an efficient approach to addressing water scarcity due to its environmental sustainability. However, the prolonged use of solar evaporators causes microbial contamination from wastewater. Inspired by the antifouling properties of polydopamine, we develop a series of mono- and dual-metal-loaded poly(norepinephrine) (PNE) nanoparticles by pre-doping multiple metal ions.
View Article and Find Full Text PDFWelding Pollen-Based Solar Evaporator for Clean Water Production.
Small
November 2024
School of Resources and Environment, Anhui Agricultural University, Hefei, Anhui, 230036, P. R. China.
Article Synopsis
- The world must balance water availability and food supply, as agricultural irrigation is the largest consumer of freshwater globally.
- A new cost-effective welding pollen-based solar evaporator (PSE) has been developed to efficiently desalinate seawater, leveraging the natural structure of plant pollen for optimal evaporation rates.
- The PSE not only demonstrates excellent mechanical stability and salt resistance but also effectively collects freshwater that can be used for growing key crops like lettuce, rice, and wheat, promoting sustainable agriculture and addressing global water scarcity.
Are Microfibers a Threat to Marine Invertebrates? A Sea Urchin Toxicity Assessment.
Toxics
October 2024
Laboratório de Ecotoxicologia, Universidade Santa Cecília (Unisanta), Rua Oswaldo Cruz, 266, Santos 11045-907, São Paulo, Brazil.
The rise of "fast fashion" has driven up the production of low-cost, short-lived clothing, significantly increasing global textile fiber production and, consequently, exacerbating environmental pollution. This study investigated the ecotoxicological effects of different types of anthropogenic microfibers-cotton, polyester, and mixed fibers (50% cotton: 50% polyester)-on marine organisms, specifically sea urchin embryos. All tested fibers exhibited toxicity, with cotton fibers causing notable effects on embryonic development even at environmentally relevant concentrations.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!