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Anti-neuraminidase and anti-hemagglutinin stalk responses to different influenza a(H7N9) vaccine regimens.
Vaccine
January 2025
Division of Microbiology and Infectious Diseases, National Institutes of Health, Rockville, MD, United States.
Introduction: Pandemic influenza vaccine development focuses on the hemagglutinin (HA) antigen for potency and immunogenicity. Antibody responses targeting the neuraminidase (NA) antigen, or the HA stalk domain have been implicated in protection against influenza. Responses to the NA and HA-stalk domain following pandemic inactivated influenza are not well characterized in humans.
View Article and Find Full Text PDFSimultaneous Detection of Five Infectious Diseases in a Single Strip: Oligo dT-Utilized Lateral Flow Immunoassay.
Anal Chem
January 2025
SB BIOSCIENCE Inc., Room 120, Venture Building, 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
Article Synopsis
- The development of a multiplex lateral flow immunoassay (LFA) allows for the simultaneous detection of five respiratory viruses, including SARS-CoV-2 and Influenza, improving diagnostic accuracy amid viral mutations.
- This platform utilizes oligonucleotide and antibody-conjugated gold nanoparticles (AuNPs) for high sensitivity and specificity in identifying these viruses.
- Rigorous testing shows no false positives, making this LFA a reliable tool for rapid diagnosis, especially useful during pandemics.
The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens.
Virulence
December 2025
Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, Yangzhou, China.
Several viruses, including influenza A virus (IAV), encode viral factors to hijack cellular RNA biogenesis processes to direct the degradation of host mRNAs, termed "host shutoff." Host shutoff enables viruses to simultaneously reduce antiviral responses and provides preferential access for viral mRNAs to cellular translation machinery. IAV PA-X is one of these factors that selectively shuts off the global host genes.
View Article and Find Full Text PDFMulticenter Evaluation of the QIAstat-Dx and the BioFire Multiplex Panel Tests for the Detection of Respiratory Pathogens.
J Med Virol
December 2024
Clinical Virology, University Hospital Basel, Basel, Switzerland.
Syndromic multiplex panel testing enables simultaneous detection of multiple respiratory pathogens, but limited data is available on the comparative diagnostic performance of different testing systems. In this multicenter prospective study, we aimed to compare the QIAstat-Dx Respiratory Panel 2.0 (QIAstat-Dx-RP2.
View Article and Find Full Text PDFSeasonal influenza vaccination coverage and the social determinants of influenza vaccination among people over 50 with diabetes in Europe: Analyzing population-based SHARE data for the 2019-2020 and 2021-2022 influenza seasons.
Vaccine
December 2024
Institute of Biometry and Epidemiology, The German Diabetes Center, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany; Chair for Medical Biometry and Epidemiology, University of Witten/Herdecke, 58448 Witten, Germany. Electronic address:
Background: Seasonal influenza vaccination coverage data for adults with chronic medical conditions are very scarce. We aimed to investigate the influenza vaccination rates and explore the common social determinants associated with vaccination in Europe across two influenza seasons.
Methods: This cross-sectional study used data from the European SHARE survey for the 2019-2020 and 2021-2022 influenza seasons.
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