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Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial.
Trials
July 2023
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Background: We have determined that the impaired accommodation of the lower esophageal sphincter (LES) underlies the pathogenesis of esophagogastric junction outflow obstruction (EGJOO). We have also found that acotiamide may treat EGJOO by improving impaired LES accommodation. The effects of acotiamide in patients with EGJOO need to be further confirmed in a prospective study.
View Article and Find Full Text PDFLaparoscopic Heller Myotomy and Dor Fundoplication for the Treatment of Esophageal Achalasia After Sleeve Gastrectomy-a Video Vignette.
Obes Surg
March 2021
Department of Biomedical Science for Health, Division of General Surgery Istitituto Clinico Sant'Ambrogio, University of Milan, Via Luigi Giuseppe Faravelli, 16, 20149, Milan, Italy.
Purpose: Esophageal dysmotility and disorders of the lower esophageal sphincter are well documented in morbidly obese patients. Esophageal achalasia has been reported in up to 1% of obese patients but the development of such esophageal motility disorder after laparoscopic sleeve gastrectomy (LSG) is extremely rare. The purpose of this video was to demonstrate the management of a type II esophageal achalasia diagnosed in a 46-year-old female patient 4-year after LSG.
View Article and Find Full Text PDFAchalasia: All Sticks in One Bundle!
Clin Gastroenterol Hepatol
May 2016
Esophageal Disorders Program, Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina.
A single center 26-year experience with treatment of esophageal achalasia: is there an optimal method?
J Pediatr Surg
July 2009
Division of General Surgery, Hospital for Sick Children, Toronto, Ontario, Canada.
Purpose: Treatment modalities for achalasia are evolving and remain controversial. Herein, we report the relative efficacy and outcomes after dilatation or myotomy in children with achalasia.
Methods: A retrospective analysis of all children treated for achalasia at a tertiary center from 1981 to 2007 was performed (n = 40).
Purpose: To define the esophageal motor disorders of achalasia and esophageal spasms and describe their presentation in the clinical setting.
Data Sources: Selected research-based articles, textbooks, and expert opinion. A case study is presented.
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