The 2,4'- and 4,4'-linked variants of the cytotoxic agent secalonic acid A and their analogues have been synthesized. Kinetic resolution of an unprotected tetrahydroxanthone scaffold followed by copper-mediated biaryl coupling allowed for efficient access to these compounds. Evaluation of the "shapeshifting" properties of 2,2'-, 2,4'-, and 4,4'-linked variants of the secalonic acids A in a polar solvent in conjunction with assays of the compounds against select cancer cell lines was conducted to study possible correlations between linkage variation and cytotoxicity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863954 | PMC |
| http://dx.doi.org/10.1021/jacs.5b09825 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Magnetic kirigami dome metasheet with high deformability and stiffness for adaptive dynamic shape-shifting and multimodal manipulation.
Sci Adv
December 2024
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA.
Soft shape-shifting materials offer enhanced adaptability in shape-governed properties and functionalities. However, once morphed, they struggle to reprogram their shapes and simultaneously bear loads for fulfilling multifunctionalities. Here, we report a dynamic spatiotemporal shape-shifting kirigami dome metasheet with high deformability and stiffness that responds rapidly to dynamically changing magnetic fields.
View Article and Find Full Text PDFFour-Dimensional Printing of Multi-Material Origami and Kirigami-Inspired Hydrogel Self-Folding Structures.
Materials (Basel)
October 2024
NanoScience Technology Center, University of Central Florida, Orlando, FL 32826, USA.
Four-dimensional printing refers to a process through which a 3D printed object transforms from one structure into another through the influence of an external energy input. Self-folding structures have been extensively studied to advance 3D printing technology into 4D using stimuli-responsive polymers. Designing and applying self-folding structures requires an understanding of the material properties so that the structural designs can be tailored to the targeted applications.
View Article and Find Full Text PDFA guide to bullvalene stereodynamics.
Chem Sci
August 2024
Department of Chemistry, University of York Heslington York YO10 5DD UK
Here, we analyze the stereodynamic properties of bullvalenes using principal moments of inertia and exit vector plots to draw comparisons with commonly used ring systems in medicinal chemistry. To aid analyses, we first classify (i) the four elementary rearrangement steps available to substituted bullvalenes, which (ii) can be described by applying positional descriptors (α, β, γ, and δ) to the substituents. We also (iii) derive an intuitive equation to calculate the number of isomers for a given bullvalene system.
View Article and Find Full Text PDFLigand Tail Controls the Conformation of Indium Sulfide Ultrathin Nanoribbons.
J Am Chem Soc
August 2024
ENSL, CNRS, Laboratoire de Chimie UMR 5182, 46 allée d'Italie, 69364 Lyon, France.
We report the conformational control of 2D ultrathin indium sulfide nanoribbons by tuning their amine ligands' alkyl chain. The initial orthorhombic InS nanoribbons bare -octylamine ligands and display a highly curved geometry with a characteristic figure of eight shapes. Exchanging the native ligand by oleylamine induces their complete unfolding to yield flat board-shaped nanoribbons.
View Article and Find Full Text PDFA 4D printed nanoengineered super bioactive hydrogel scaffold with programmable deformation for potential bifurcated vascular channel construction.
J Mater Chem B
August 2024
Department of Material Engineering, Indian Institute of Science, Bangalore, Karnataka 560012, India.
Four-dimensional (4D) printing of hydrogels enabled the fabrication of complex scaffold geometries out of static parts. Although current 4D fabrication strategies are promising for creating vascular parts such as tubes, developing branched networks or tubular junctions is still challenging. Here, for the first time, a 4D printing approach is employed to fabricate T-shaped perfusable bifurcation using an extrusion-based multi-material 3D printing process.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!