AI Article Synopsis
- - The study investigates the role of Adrenomedullin (ADM) in regulating inflammatory cytokines and chemokines in the oviduct of women with tubal ectopic pregnancy (tEP), given that inflammation in the oviduct is linked to tEP occurrences.
- - Researchers collected tissue samples from women with tEP and controls and used PCR and protein microarray methods to analyze the mRNA and protein levels of inflammatory markers.
- - Findings indicate that ADM can upregulate some inflammatory markers in tEP cases but may also down-regulate them with prolonged exposure, suggesting that low levels of ADM could heighten the risk of tEP by reducing anti-inflammatory responses.
Article Abstract
Background: The occurrence of tubal ectopic pregnancy (tEP) is related to the inflammation of the oviduct. Recently, Adrenomedullin (ADM) was found highly expression in human oviduct. The current study is to investigate whether ADM have a modulatory action on inflammatory cytokines and chemokines in oviductal tissue from women with tubal ectopic pregnancy (tEP).
Methods: Oviductal isthmus samples were collected from women with tEP undergoing salpingectomy, and women undergoing hysterectomy for benign gynaecological conditions. The mRNA and protein levels of inflammatory cytokines/chemokines were assayed by PCR (n = 6 for tEP, n = 5 for controls) and protein microarray methods (n = 5 for both tEP and controls) respectively.
Results: Some of the inflammatory cytokines/chemokines were upregulated by ADM in oviducts from tEP patients at both mRNA and protein levels. Incubation of oviduct from tEP patients with ADM for 24 h down-regulated some of these cytokines/chemokines.
Conclusion: Our results suggest an additional mechanism whereby ADM insufficiency may increase the susceptibility to tEP through diminished anti-inflammatory activity. The actual impact of the relationship between ADM and inflammatory process on tubal implantation needs further exploration.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635555 | PMC |
| http://dx.doi.org/10.1186/s12958-015-0117-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!