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A plasmid-chromosome crosstalk in multidrug resistant enterobacteria.
Nat Commun
December 2024
Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Conjugative plasmids promote the dissemination and evolution of antimicrobial resistance in bacterial pathogens. However, plasmid acquisition can produce physiological alterations in the bacterial host, leading to potential fitness costs that determine the clinical success of bacteria-plasmid associations. In this study, we use a transcriptomic approach to characterize the interactions between a globally disseminated carbapenem resistance plasmid, pOXA-48, and a diverse collection of multidrug resistant (MDR) enterobacteria.
View Article and Find Full Text PDFMagnitude and associated factors of preoperative anemia among adult elective surgical patients at Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia, 2024.
Front Med (Lausanne)
December 2024
Reaserch Directorate Office and Nursing Education Department, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Background: Preoperative anemia is a common hematologic public health problem among elective surgical patients. Preoperative anemia complications independently increase the risk of perioperative complications and mortality rate. Despite this complication, there is a scarcity of evidence on the prevalence and associated factors of preoperative anemia among adult elective surgical patients in Ethiopia.
View Article and Find Full Text PDFPorcine circovirus type 2 (PCV2) is the major causative agent of postweaning multisystemic wasting syndrome which leads to significant economic losses in the global swine industry. In China, there is a widespread dissemination of PCV2 infection in the pig population. Serological diagnosis of the disease is considered as an effective control measure.
View Article and Find Full Text PDFGenetic Diversity of with Attention to Clinical Features in Patients Originated from Three Endemic Provinces in the North and South of Iran.
Iran J Parasitol
January 2024
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Background: is one of the neglected tropical diseases. We aimed to verify the genetic diversity of with attention to clinical features of the infection in patients using the 1 gene and DNA sequencing.
Methods: Using parasitological methods, was isolated from stool samples of patients who had been referred to Tehran University of Medical Sciences, Tehran, Iran.
Engaging rural communities in Bangladesh to tackle antimicrobial resistance through the Community Dialogue Approach: a process evaluation protocol for COSTAR project in Cumilla, Bangladesh.
Front Public Health
December 2024
Nuffield Centre for International Health and Development, Leeds Institute for Health Sciences, University of Leeds, Leeds, United Kingdom.
Introduction: Antimicrobial resistance (AMR) is a global problem and is especially threatening for low-and-middle income countries like Bangladesh. The COSTAR (Community-led Solutions to Antimicrobial Resistance) project includes a Randomised Control Trial (RCT) which aims to evaluate the effectiveness of the Community Dialog Approach (CDA) to improve levels of correct and appropriate knowledge and reported practice about antibiotics, antibiotic use, and antibiotic resistance (ABR) from a One Health perspective, among adult community members in 5 selected sub-districts of Cumilla. The CDA is a community engagement approach involving community members in active discussions also known as Community Dialogs (CD), run by local facilitators.
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