AI Article Synopsis
- - We studied the levels of transcription factors SP1 and SP4 in blood cells of 11 patients with first-episode psychosis and 14 healthy individuals.
- - Our analysis revealed that patients had lower SP1 and SP4 levels, which were positively linked to the volume of the right hippocampus.
- - These findings suggest that SP1 and SP4 could play a role in the molecular mechanisms associated with the development of psychosis.
Article Abstract
We assessed specificity protein 1 (SP1) and 4 (SP4) transcription factor levels in peripheral blood mononuclear cells and conducted a voxel-based morphometry analysis on brain structural magnetic resonance images from 11 patients with first-episode psychosis and 14 healthy controls. We found lower SP1 and SP4 levels in patients, which correlated positively with right hippocampal volume. These results extend previous evidence showing that such transcription factors may constitute a molecular pathway to the development of psychosis.
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| http://dx.doi.org/10.1192/bjp.bp.114.152140 | DOI Listing |
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