AI Article Synopsis
- * This study examines whether the specific type of excitatory projection neuron influences the formation of inhibitory synapses, focusing on the conversion of layer 2/3 callosal projection neurons into induced corticofugal projection neurons.
- * Findings reveal that these reprogrammed neurons receive enhanced inhibitory signals similar to those in layer 5 neurons, indicating that the identity of projection neurons affects how inhibitory inputs are established in the cortical microcircuit.
Article Abstract
During development of the cerebral cortex, local GABAergic interneurons recognize and pair with excitatory projection neurons to ensure the fine excitatory-inhibitory balance essential for proper circuit function. Whether the class-specific identity of projection neurons has a role in the establishment of afferent inhibitory synapses is debated. Here, we report that direct in vivo lineage reprogramming of layer 2/3 (L2/3) callosal projection neurons (CPNs) into induced corticofugal projection neurons (iCFuPNs) increases inhibitory input onto the converted neurons to levels similar to that of endogenous CFuPNs normally found in layer 5 (L5). iCFuPNs recruit increased numbers of inhibitory perisomatic synapses from parvalbumin (PV)-positive interneurons, with single-cell precision and despite their ectopic location in L2/3. The data show that individual reprogrammed excitatory projection neurons extrinsically modulate afferent input by local PV(+) interneurons, suggesting that projection neuron class-specific identity can actively control the wiring of the cortical microcircuit.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794746 | PMC |
| http://dx.doi.org/10.1016/j.neuron.2015.10.006 | DOI Listing |
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