AI Article Synopsis
- The study identifies a dementia subgroup linked to diabetes mellitus, termed "diabetes-related dementia" (DrD), and explores the role of oxidative stress in its development.
- In analyzing 175 Alzheimer's patients, researchers found key differences in antioxidant levels and oxidative damage markers between the DrD group and other groups with diabetes.
- Results indicate that lower antioxidant levels and higher oxidative damage correlate with cognitive decline in patients with DrD, suggesting these factors play a significant role in its pathophysiology.
Article Abstract
Aims: We previously found that there was a dementia subgroup with characteristics predominantly associated with diabetes mellitus (DM)-related metabolic abnormalities, referred to as "diabetes-related dementia (DrD)." We determined the possible role of oxidative stress in the pathophysiology of DrD.
Methods: In a 2013 study, we classified 175 patients with clinically diagnosed Alzheimer's disease (AD) and DM into four subgroups based on brain imaging. Among them, we measured endogenous plasma anti-oxidants, such as albumin, unconjugated bilirubin and uric acid, and urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in 58 patients of an AD group showing decreased regional cerebral blood flow of the parietotemporal lobe on single-photon emission computed tomography (AD+DM group), and in 35 patients of a DrD group showing neither decreased regional cerebral blood flow of the parietotemporal lobe nor cerebrovascular disease on magnetic resonance imaging, which is strongly associated with DM-related factors. A total of 31 patients with AD and without DM (AD-DM group) were enrolled as a control group.
Results: The DrD group showed a significant decrease in plasma levels of anti-oxidants, and a significant increase in urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane levels in contrast to the AD-DM and AD+DM groups. Cognitive performance was negatively correlated with urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane levels in the DrD group.
Conclusions: These results strongly suggest that a decrease in anti-oxidant levels and an increase in oxidative damage might be involved in the pathophysiology and cognitive decline associated with DrD. Geriatr Gerontol Int 2016; 16: 1312-1318.
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| http://dx.doi.org/10.1111/ggi.12645 | DOI Listing |
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