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| http://dx.doi.org/10.1001/jama.2015.10347 | DOI Listing |
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Differences in HIV risk factors between South African adolescents and adult women and their association with sexually transmitted infections.
Sex Transm Infect
December 2024
Centre for the Aids Programme of Research in South Africa, Durban, South Africa
Article Synopsis
- In sub-Saharan Africa, girls aged 15-19 represent 86% of HIV infections, underscoring the need to understand risk factors affecting them compared to adult women in South Africa.
- A study of 305 adolescent girls and 114 adult women in two South African provinces revealed that while adults reported higher risk sexual behaviors, adolescents had a higher prevalence of STIs (62.8% vs 34.0% in the Western Cape).
- Factors like earlier sexual debut and the use of intravaginal sexual enhancers among adolescents were significant, and behavioral risk factors such as the number of sexual partners and recent sexual activity were linked to STI presence in both age groups.
Management and prevention of Neisseria meningitidis and Neisseria gonorrhoeae infections in the context of evolving antimicrobial resistance trends.
Eur J Clin Microbiol Infect Dis
November 2024
GSK, Rockville, MD, USA.
Purpose: To describe the relationships between Neisseria meningitidis (NM) and Neisseria gonorrhoeae (NG) at genetic, population, and individual levels; to review historical trends in antimicrobial resistance (AMR); to review the treatment and preventive landscapes and explore their potential impact on AMR.
Methods: A narrative literature search was conducted in PubMed, with searches restricted to 2003-2023 and additional articles included based on expertise.
Results: NM and NG are closely related bacterial pathogens causing invasive meningococcal disease (IMD) and gonorrhea, respectively.
Immunity Dynamics of Serogroups ACYW from Birth and Following Vaccination.
Vaccines (Basel)
November 2024
Guangdong Provincial Institute of Public Health, Guangzhou 511430, China.
: Serosurveillance of epidemic cerebrospinal meningitis (ECM) in healthy individuals is crucial for assessing disease risk and evaluating the effectiveness of vaccinations. However, this practical work is rare in China. : We conducted cross-section serosurveillance in Guangzhou, Zhanjiang, and Heyuan in Guangdong Province, measuring Anti-Nm IgG with serogroups A, C, Y, and W, and analyzed the trends using a generalized additive model (GAM).
View Article and Find Full Text PDFCoagulative Biomarkers Differently Predict Clinical Outcomes in Invasive Infections Caused by Neisseria Meningitidis and Streptococcus Pneumoniae.
Am J Med
November 2024
Infectious Disease Unit, Department of Medicine, University of Udine, Udine, Italy.
Background: Coagulation plays a crucial role in innate immune response to invasive infections. Coagulative biomarkers might predict clinical outcomes differently, depending on etiology.
Methods: A retrospective study was conducted during a 79-month period, recruiting 90 patients with meningitis or bloodstream infection caused by Neisseria meningitidis (n = 47) or Streptococcus pneumoniae (n = 43), median age 19 and 58 years, respectively.
Randomized trial showing persistence of hSBA titers elicited by a pentavalent meningococcal MenABCWY vaccine for up to 4 years following a primary series and safety and immunogenicity of a booster dose.
Vaccine
January 2025
Pfizer R&D UK Limited, Orega, Marlow International, Parkway, Marlow, SL7 1YL, UK,. Electronic address:
Background: Vaccination against 5 prominent meningococcal serogroups (A/B/C/W/Y) is necessary for broad disease protection. We report immunopersistence through 4 years after a 2-dose (6-month interval) pentavalent MenABCWY primary vaccine series and safety and immunogenicity of a booster administered 4 years after primary vaccination.
Methods: This randomized, active-controlled, observer-blinded study was conducted in the United States and Europe.
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