AI Article Synopsis
- The Wnt signaling pathway is crucial for various biological processes like cell renewal, tumor growth, and bone dynamics.
- It consists of two main pathways: the canonical Wnt-β-catenin pathway and the non-canonical Wnt-calcium pathway.
- miRNAs significantly regulate the Wnt signaling pathway at multiple levels, suggesting potential for diagnostics and future therapies.
Article Abstract
Wnt signaling pathway plays an important role in cell renewal, tumorigenesis, organogenesis, bone formation and bone resorption. Wnt signaling pathway is divided into two outlets: Wnt-β-catenin pathway (canonical pathway) and Wnt-calcium pathway (non-canonical pathway). miRNAs play a key role in the regulation of Wnt signaling pathway. In this review, we highlight the basic indulgent of miRNAs-mediated regulation of Wnt signaling pathway. We focus on the role of miRNAs at different levels of Wnt signaling: signaling molecules, their associated signaling proteins, regulatory proteins, transcription factors and related cytokines. Finally, we concluded that these multiple levels of targeting may have diagnostic potential as well as therapeutic prospective in future treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/10799893.2015.1080273 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!