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Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction.
Proc Natl Acad Sci U S A
January 2025
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.
Dysregulation of GABAergic inhibition is associated with pathological pain. Consequently, enhancement of GABAergic transmission represents a potential analgesic strategy. However, therapeutic potential of current GABA agonists and modulators is limited by unwanted side effects.
View Article and Find Full Text PDFConverging inputs compete at the lateral parabrachial nuclei to dictate the affective-motivational responses to cold pain.
Pain
November 2024
Center for Neuroscience, Indian Institute of Science, Bengaluru, Karnataka, India.
Article Synopsis
- The mechanisms behind emotional responses to chronic pain are not well understood.
- In mice with chemotherapy-induced peripheral neuropathy (CIPN), licking affected areas becomes a strong coping mechanism, especially in response to cold stimuli.
- Research identified the lateral parabrachial nucleus (LPBN) as crucial in managing this licking behavior by responding to pain signals from the spinal cord and brain, highlighting the complex interaction between pain and emotional responses.
MiR-200a-3p Attenuates Neuropathic Pain by Suppressing the Bromodomain-Containing Protein 3-Nuclear Factor-κB Pathway.
J Biochem Mol Toxicol
December 2024
Department of Anesthesia, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
MicroRNAs (miRNAs) have key roles in the pathological processes of neuropathic pain. Here, our aim was to elucidate the function of miR-200a-3p as well as its related regulatory mechanism in neuropathic pain. An animal model of neuropathic pain was established by chronic constriction injury (CCI) induction.
View Article and Find Full Text PDFTargeted delivery of a selenium-sulfa compound via cationic starch microparticles: Modulation of oxidative stress and pain pathways in fibromyalgia-like symptoms in mice.
Int J Biol Macromol
January 2025
Laboratório de Pesquisa em Farmacologia Bioquímica (LaFarBio), Universidade Federal de Pelotas (UFPel), Campus Capão do Leão, 96010-900 Pelotas, RS, Brazil. Electronic address:
Cationic starch microparticles (CStMPs) loaded with 4-amino-3 -(phenylselenyl)benzenesulfonamide (4-APSB) were prepared and investigated in a model of fibromyalgia (FM) induced by intermittent cold stress (ICS) in male and female Swiss mice. The CStMPs/4-APSB were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) spectroscopy, zeta potential, and particle size measurements, providing information about their chemical composition, surface charge, morphology/microstructure, and size (1.50 ± 0.
View Article and Find Full Text PDFPharmacological investigation of natural compounds for therapeutic potential in neuropathic pain.
Nat Prod Res
December 2024
Department of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam bin Abdul Aziz University, Al-Kharj, Saudi Arabia.
Article Synopsis
- The research investigates the effects of three natural compounds—berbamine, bergapten, and carveol—on neuroinflammation and neuropathic pain caused by chronic constriction injury (CCI-NP).
- The study employed various computational and experimental techniques, including molecular docking and dynamic simulations to evaluate how these compounds interact with key inflammatory targets like COX-2, TNF-α, and NF-κB.
- Results indicated that berbamine demonstrated significant neuroprotective effects, improving pain-related behaviors and reducing oxidative stress markers while inhibiting overexpression of inflammatory factors.
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