AI Article Synopsis
- Interactions between DNA/RNA and peptides are essential in nature, impacting many biological processes.
- Naturally occurring small molecules, like echinomycin, utilize peptide and DNA intercalators to enhance their biological effects through synergistic interactions.
- Synthetic short peptides serve as recognition units or carriers for bioactive compounds, leading to the development of new intercalators with unique properties for DNA/RNA interaction.
Article Abstract
Interactions between DNA/RNA and huge variety of peptides are quite common in nature, controlling vast number of processes. Also, there are several naturally occurring small molecules which contain peptide and DNA intercalator in structure, whereby their biological activity is based on synergistic interactions of both components; for instance bis-intercalator echinomycin. Versatility of synthetic approaches to short peptides allowed their usage as simple recognition units within the DNA or RNA grooves or as backbone carriers for variety of bioactive substituents attached to amino acid side chains, one of very popular examples being PNAs. Such peptide-backbones were also used for synthesis of novel intercalators and poly-intercalators, many of them showing intriguing novel DNA/RNA interacting properties.
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| http://dx.doi.org/10.2174/138920371702160209124439 | DOI Listing |
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