AI Article Synopsis
- Primary graft failure occurred after cord blood transplantation in a patient with acute lymphoblastic leukemia, prompting a second transplantation using haploidentical peripheral blood.
- The conditioning regimen involved administering fludarabine, cyclophosphamide, and total body irradiation, followed by immunosuppressants like tacrolimus, prednisolone, and rabbit anti-thymocyte globulin.
- Engraftment was confirmed on day 9, and both acute and chronic graft-versus-host disease were manageable, suggesting the regimen is effective for quick recovery and complication control.
Article Abstract
Primary graft failure occurred after cord blood transplantation for a patient with acute lymphoblastic leukemia. The second transplantation was performed using haploidentical peripheral blood. The conditioning regimen consisted of fludarabine (day -1; 30 mg/m(2)), cyclophosphamide (day -1; 2,000 mg/m(2)), and total body irradiation (day -1; 2 Gy). The immunosuppressants contained tacrolimus, prednisolone, and rabbit anti-thymocyte globulin (day -3 to -2; total dose: 3.75 mg/kg). The engraftment was confirmed on day 9. Both acute and chronic graft-versus-host disease were controllable. The present regimen appears to be suitable for immediate management, fast engraftment, and the durable control of complications.
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| http://dx.doi.org/10.2169/internalmedicine.54.4809 | DOI Listing |
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