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Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data.
Sci Rep
January 2025
Laboratorio de Interacciones Hospedero-Patógeno, Unidad de Biología Molecular, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Tuberculosis is a global public health concern, and understanding Mycobacterium tuberculosis transmission routes and genetic diversity of M. tuberculosis is crucial for outbreak control. This study aimed to explore the genomic epidemiology and genetic diversity of M.
View Article and Find Full Text PDFEfflux transporters in drug disposition during pregnancy.
Drug Metab Dispos
January 2025
Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.
Evidence-based dose selection of drugs in pregnant women has been lacking because of challenges in studying maternal-fetal pharmacokinetics. Hence, many drugs are administered off-label during pregnancy based on data obtained from nonpregnant women. During pregnancy, drug transporters play an important role in drug disposition along with known gestational age-dependent changes in physiology and drug-metabolizing enzymes.
View Article and Find Full Text PDFPhysiological impact of secondary nanoplastics on aquatic inhabitants in special reference to immunotoxicity.
Environ Monit Assess
January 2025
Department of Animal Sciences, School of Life Sciences, Central University of Himachal Pradesh, Kangra, 176206, India.
Nanoplastic (NP) pollution poses serious health hazards to aquatic ecosystems, impacting various physiological systems of aquatic organisms. This review examines the complex interplay between NPs and different physiological systems. In the digestive system, NPs downregulate the hsp70-like gene in Mytilus galloprovincialis, leading to decreased metabolic processes and impaired digestion.
View Article and Find Full Text PDFMimicking the reactivity of drug metabolites: Biomolecule conjugation of an electrochemically-generated, reactive oxidation product of the antibiotic minocycline.
J Pharm Biomed Anal
January 2025
Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 48, Münster 48149, Germany. Electronic address:
Minocycline is an antibiotic of the tetracycline family which is widely used to treat a range of medical conditions. Although it has been in use for more than 50 years, little information is available on its metabolism in the human body. In this study, we simulate the biotransformation of minocycline by means of electrochemistry coupled to mass spectrometry.
View Article and Find Full Text PDFSingle-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair.
Adv Wound Care (New Rochelle)
January 2025
Translational Medicine Center, Baotou Central Hospital (Baotou Clinical Medical College, Affiliated to Inner Mongolia Medical University), Baotou, China.
Wound healing is a dynamic process involving multiple cell types and signaling pathways. Dermal sheath cells (DSCs), residing surrounding hair follicles, play a critical role in tissue repair, yet their regulatory mechanisms remain unclear. This study used single-cell proteomics with the mouse model to explore DSC function across different healing stages.
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