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Thyroid disorders in patients with human immunodeficiency virus infection: a meta-analysis.
AIDS Res Ther
January 2025
University of Khartoum, Khartoum, Sudan.
Background: Thyroid disorders have significant clinical sequelae, including impaired growth in children, metabolic abnormalities, and impaired cognitive function. However, available studies on burden of thyroid diseases in people with human immunodeficiency virus (HIV), particularly its prevalence and its interaction with HIV related factors (like CD4 count), are controversial. This review aimed to provide a comprehensive summary and analysis on the extent of thyroid dysfunctions in this population.
View Article and Find Full Text PDFLongitudinal Assessment of FT3 to FT4 Conversion Ratio in Predicting the Efficacy of First-Line Pembrolizumab-Based Therapy in Advanced Non-Small Cell Lung Cancer: A Propensity-Score Matching Analysis of Data from the National Drug Monitoring Agency.
Curr Oncol
December 2024
Department of Oncology and Hematology, Medical Oncology Unit, Central Hospital of Belcolle, 01100 Viterbo, Italy.
Baseline thyroid function, as measured by the fT3 to fT4 ratio, has been shown to influence the prognosis of advanced cancer patients receiving active treatments. Although immune checkpoint blockade can alter the balance of thyroid hormones, this interaction has not been thoroughly investigated. The present research sought to determine whether changes in the fT3/fT4 ratio could affect the survival outcomes of patients with advanced non-small cell lung cancer (NSCLC) who were undergoing pembrolizumab-based therapies.
View Article and Find Full Text PDFBackground Roxadustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor used in renal anemia treatment, has been associated with thyroid hormone suppression. This study investigated the patterns of thyroid profile changes following roxadustat administration and their clinical implications. Methods In this retrospective study (2019-2023) at Shenzhen Second People's Hospital, patients were categorized based on TSH reduction during follow-up (≥50% decrease vs<50% decrease).
View Article and Find Full Text PDFEuthyroid sick syndrome predicts the risk of ischemic stroke-associated pneumonia in the acute stage of ischemic stroke: a nested case-control study.
Front Endocrinol (Lausanne)
November 2024
Department of Neurology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, China.
Article Synopsis
- Ischemic stroke-associated pneumonia (iSAP) affects around 10% of stroke patients during their hospital stay, highlighting the need for better predictive tools as current scales are ineffective.
- This study analyzed 1,767 acute ischemic stroke patients to assess the predictive value of euthyroid sick syndrome (ESS) as a biomarker for iSAP, finding that older age and comorbidities like atrial fibrillation and COPD increase the risk.
- Results indicate that ESS is a significant predictor of iSAP, with a sensitivity of 35.64% and specificity of 87.92%, suggesting its potential use in identifying at-risk stroke patients early on.
Association between thyroid function and prognosis of severe COVID-19 among patients with SARS-CoV-2 infection: a retrospective cohort study in China.
Front Endocrinol (Lausanne)
October 2024
Department of Endocrinology, Shanghai Public Health Clinical Center, Shanghai, China.
Objective: This study aims to examine the thyroid hormone profile and its association with severe coronavirus disease 2019 (COVID-19) in patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: This retrospective cohort study enrolled patients admitted to a tertiary hospital due to SARS-CoV-2 infection between February 18 and May 18, 2022. Clinical data were collected retrospectively from the electronic medical record system.
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