Background: Multiple pituitary hormone deficiency and Turner syndrome have overlapping features in peripubertal girls and is a diagnostic challenge.
Case Characteristics: 16-year-old girl having Turner phenotype undergoing evaluation for severe short stature and pubertal arrest.
Observation: 45,X karyotype, and multiple pituitary hormone deficiency with empty sella.
Intervention: Levothyroxine, growth hormone and ethinyl-estradiol replacement resulted in 11 cm height gain with attainment of puberty over 2 years.
Message: Patients of Turner syndrome with height <3rd percentile (Turner specific charts) warrant additional pathology evaluation.
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