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Effect of Thromboprophylaxis on Clinical Outcomes After COVID-19 Hospitalization.
Ann Intern Med
April 2023
Division of Hematology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina (T.L.O.).
Article Synopsis
- - The study aimed to evaluate whether anticoagulation with apixaban is more effective than a placebo in preventing death and thromboembolic complications for patients discharged after being hospitalized with COVID-19.
- - Conducted across 127 U.S. hospitals from 2021 to 2022, the trial included adults who were hospitalized for more than 48 hours and had no contraindications to anticoagulation.
- - Results showed no significant difference in the incidence of the main outcome between the apixaban group (2.13%) and the placebo group (2.31%), indicating that extended thromboprophylaxis post-discharge may not provide additional benefits.
A dusty compact object bridging galaxies and quasars at cosmic dawn.
Nature
April 2022
Cosmic Dawn Center (DAWN), Copenhagen, Denmark.
Understanding how super-massive black holes form and grow in the early Universe has become a major challenge since it was discovered that luminous quasars existed only 700 million years after the Big Bang. Simulations indicate an evolutionary sequence of dust-reddened quasars emerging from heavily dust-obscured starbursts that then transition to unobscured luminous quasars by expelling gas and dust. Although the last phase has been identified out to a redshift of 7.
View Article and Find Full Text PDFMicrowave background temperature at a redshift of 6.34 from HO absorption.
Nature
February 2022
Institut de Radioastronomie Millimétrique, Saint Martin d'Héres, France.
Distortions of the observed cosmic microwave background provide a direct measurement of the microwave background temperature at redshifts from 0 to 1 (refs. ). Some additional background temperature estimates exist at redshifts from 1.
View Article and Find Full Text PDFRapidly star-forming galaxies adjacent to quasars at redshifts exceeding 6.
Nature
May 2017
Korea Astronomy and Space Science Institute, Daedeokdae-ro 776, Yuseong-gu Daejeon 34055, South Korea.
The existence of massive (10 solar masses) elliptical galaxies by redshift z ≈ 4 (refs 1, 2, 3; when the Universe was 1.5 billion years old) necessitates the presence of galaxies with star-formation rates exceeding 100 solar masses per year at z > 6 (corresponding to an age of the Universe of less than 1 billion years). Surveys have discovered hundreds of galaxies at these early cosmic epochs, but their star-formation rates are more than an order of magnitude lower.
View Article and Find Full Text PDFBackground: Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improving child survival has varied markedly, highlighting a crucial need to further examine potential drivers of accelerated or slowed decreases in child mortality. The Global Burden of Disease 2015 Study (GBD 2015) provides an analytical framework to comprehensively assess these trends for under-5 mortality, age-specific and cause-specific mortality among children under 5 years, and stillbirths by geography over time.
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