AI Article Synopsis
- The study aimed to assess how polypharmacy (taking 6 or more medications) affects adherence to evidence-based medications (EBM) in patients post-percutaneous coronary intervention (PCI).
- A retrospective analysis of 557 PCI patients showed that those with polypharmacy had lower adherence rates to both primary and secondary medications compared to those without polypharmacy.
- The findings suggest that having multiple medications may hinder patients' ability to adhere to their prescribed treatments, signaling a need for further research into factors influencing long-term adherence.
Article Abstract
Background: The primary objective of this study was to evaluate the impact of polypharmacy on primary and secondary adherence to evidence-based medication (EBM) and to measure factors associated with non-adherence among patients who underwent percutaneous coronary intervention (PCI).
Methods: We conducted a retrospective analysis for patients who underwent PCI at a tertiary cardiac care hospital in Qatar. Patients who had polypharmacy (defined as ≥6 medications) were compared with those who had no polypharmacy at hospital discharge in terms of primary and secondary adherence to dual antiplatelet therapy (DAPT), beta-blockers (BB), angiotensin converting enzyme inhibitors (ACEIs) and statins.
Results: A total of 557 patients (mean age: 53±10 years; 85%; males) who underwent PCI were included. The majority of patients (84.6%) received ≥6 medications (polypharmacy group) while only 15.4% patients received ≥5 medications (nonpolypharmacy group). The two groups were comparable in term of gender, nationality, socioeconomic status and medical insurance. The non-polypharmacy patients had significantly higher adherence to first refill of DAPT compared with patients in the polypharmacy group (100 vs. 76.9%; p=0.001). Similarly, the non-polypharmacy patients were significantly more adherent to secondary preventive medications (BB, ACEI and statins) than the polypharmacy group.
Conclusion: In patients who underwent PCI, polypharmacy at discharge could play a negative role in the adherence to the first refill of EBM. Further studies should investigate other parameters that contribute to long term non-adherence.
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| http://dx.doi.org/10.2174/1570161113666151030105805 | DOI Listing |
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