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| http://dx.doi.org/10.1177/2049463712437628 | DOI Listing |
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Estimated equipotent conversion ratios of morphine, sufentanil and fentanyl as continuous infusion in neonatal intensive care units: a pharmacoepidemiologic cohort study.
Eur J Clin Pharmacol
December 2024
Neonatal Intensive Care Unit, CHI Créteil, 40 Avenue de Verdun, 94000, Créteil, France.
Purpose: Opioids are frequently used to treat pain in neonatal intensive care units (NICU) with fentanyl, morphine and sufentanil being mainly used agents. Equianalgesic potency between opioids is not clearly described in the neonatal population. The aim of this study was to compare theoretical and actual equipotent conversion ratios between morphine, sufentanil and fentanyl based on prescriptions.
View Article and Find Full Text PDFNew insights in the mechanisms of opioid analgesia and tolerance: Ultramicronized palmitoylethanolamide down-modulates vascular endothelial growth factor-A in the nervous system.
Pharmacol Res
November 2024
Department of Neuroscience, Psychology, DrugResearch and Child Health - NEUROFARBA - Section of Pharmacology andToxicology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy.
Article Synopsis
- Growing evidence shows that opioid analgesics, like morphine, can affect blood vessel formation (angiogenesis), which is linked to pain.
- The study tested the effects of N-palmitoylethanolamine (PEA) and the anti-VEGF-A drug bevacizumab on morphine tolerance and pain relief, finding that PEA delays tolerance and enhances pain relief by reducing VEGF-A levels in the nervous system.
- Both PEA and bevacizumab, when used with morphine, not only improved pain management but also decreased the expression of pain-related genes, suggesting a potential new approach to pain treatment that targets angiogenesis.
Conversion ratios: Why is it so challenging to construct opioid conversion tables?
J Opioid Manag
May 2024
Department of Palliative and Supportive Care, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Standardizing opioid management is challenging due to the absence of a ceiling dose, the unknown ideal therapeutic plasma level, and the lack of an clear relationship between dose and therapeutic response. Opioid rotation or conversion, which is switching from one opioid, route of administration, or both, to another, to improve therapeutic response and reduce toxicities, occurs in 20-40 percent of patients treated with opioids. Opioid conversion is often needed when there are adverse effects, toxicities, or inability to tolerate a certain opioid formulation.
View Article and Find Full Text PDFMorphine Equianalgesic Dose Chart in the Emergency Department.
J Educ Teach Emerg Med
July 2022
University of California Irvine, Department of Emergency Medicine, Orange, CA.
Audience: The lecture and infographic are targeted towards Emergency Medicine physicians and residents.
Introduction: Pain is the most common presenting symptom in the emergency department.1 Various classes of medications are used to treat acute and chronic pain.
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