AI Article Synopsis
- Changes in the default mode network (DMN) activity are early indicators of Alzheimer’s disease (AD) and are linked to specific Alzheimer’s-related Aβ pathology.
- A study involving 21 AD patients and 10 controls examined cognitive profiles, DMN connectivity, and cerebrospinal fluid (CSF) biomarker levels.
- Results show altered DMN activity in AD patients, particularly in the posterior cingulate cortex (PCC), which correlates with cognitive function and reduced CSF Aβ1-42, suggesting the PCC and retrosplenial cortex are crucial in understanding AD’s pathogenesis and cognitive effects.
Article Abstract
Background: Changes in the default mode network (DMN) activity are early features of Alzheimer's disease (AD) and may be linked to AD-specific Aβ pathology.
Methods: Cognitive profiles; DMN connectivity alterations; and cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42, total tau, phosphorylated tau 181, and α-synuclein levels were studied in 21 patients with AD and 10 controls.
Results: DMN activity is altered in AD. Posterior cingulate cortex (PCC) functional connectivity with other parts of DMN was related to cognitive function scores. The reduction of connectivity of the dorsal PCC with the retrosplenial cortex on the right side was closely related to decreased CSF Aβ1-42 levels in patients with AD.
Conclusions: The dorsal PCC and retrosplenial cortex may have special importance in the pathogenesis and cognitive findings of AD.
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| http://dx.doi.org/10.1016/j.archger.2015.09.010 | DOI Listing |
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