Several types of collaboration are being pursued to identify, validate and apply new biomarkers. Here, we highlight examples of such initiatives and discuss the challenges, approaches to address these challenges and key factors for success.
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Cost-Effective Laser Powder Bed Fusion of Ti-6Al-4V Grade 5: The Effect of Expanding Powder Size Distribution on Mechanical Performance.
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Department of Aerospace Engineering, Inha University, Incheon 22212, Republic of Korea.
This study aims to assess the feasibility of expanding the powder size distribution (PSD) of Ti-6Al-4V grade 5 powder for LPBF to achieve cost reduction. Parameter optimization to minimize the degradation of mechanical properties due to the expanded particle size distribution was conducted. Mechanical tests for specimens built using optimized parameters revealed minor reductions in strength: 3.
View Article and Find Full Text PDFBackground: The Wound Care Collaborative Community (WCCC) assesses shortcomings and unmet needs in wound care by partnering with key stakeholders, such as the National Institutes of Health, the US Food and Drug Administration (FDA), industry leaders, and expert health care providers and researchers, to advance the study of wound healing. Through this work, the WCCC has identified a few key barriers to innovation in wound care. The WCCC aims to accelerate the development of science-based, patient-centered solutions and address public policy challenges related to ensuring patients receive early access to innovative treatment options.
View Article and Find Full Text PDFDietary RNA from Torula Yeast Prevents Capillary Regression in Atrophied Skeletal Muscle in Rats.
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Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, 7-10-2, Tomogaoka, Suma-ku, Kobe 654-0142, Japan.
Chronic neuromuscular inactivity induces capillary regression within skeletal muscle. The objective of this study was to investigate the potential effects of dietary nucleic acids in counteracting the capillary reduction linked to chronic neuromuscular inactivity in the soleus muscle. The study utilized four distinct groups of female Wistar rats: a control group (CON), a hindlimb-unloading group (HU), an HU group supplemented with DNA (HU + DNA), and an HU group supplemented with RNA (HU + RNA).
View Article and Find Full Text PDFWater quality prediction and carbon reduction mechanisms in wastewater treatment in Northwest cities using Random Forest Regression model.
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School of Public Administration, Guangzhou University, Guangzhou, 510006, China.
With the accelerated urbanization and economic development in Northwest China, the efficiency of urban wastewater treatment and the importance of water quality management have become increasingly significant. This work aims to explore urban wastewater treatment and carbon reduction mechanisms in Northwest China to alleviate water resource pressure. By utilizing online monitoring data from pilot systems, it conducts an in-depth analysis of the impacts of different wastewater treatment processes on water quality parameters.
View Article and Find Full Text PDFADNI Private Partners Scientific Board (PPSB) Diversity, Equity, and Inclusion (DE&I) Working Group: A new collaboration that crosses boundaries for industry, academia, and under-represented patients.
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Cognition Therapeutics, Purchase, New York, USA.
The Alzheimer's Disease Neuroimaging Initiative (ADNI) Private Partners Scientific Board (PPSB) Diversity, Equity, and Inclusion Working Group (DE&I WG) was established to work with the ADNI3 Diversity Task Force to provide an industry perspective on increasing the representation of diverse participants in ADNI3 and to build precompetitive cross-industry knowledge in engagement and recruitment of under-represented participants (URPs). In this article, we review and highlight the role and ongoing activities within the ADNI PPSB DE&I WG and provide a cross-industry perspective on areas where precompetitive collaboration can improve the inclusiveness in clinical trials, drawing on examples from ADNI4. HIGHLIGHTS: New collaboration crosses boundaries to allow PPSB DE&I WG members to work together in a preproprietary way.
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