AI Article Synopsis
- The orderly execution of DNA replication and chromosome segregation is crucial for stable genetic material transmission.
- The cohesin complex plays a key role in connecting sister chromatids and ensuring their proper cohesion during DNA replication.
- This review highlights recent advances in understanding how sister chromatid cohesion is regulated throughout the mitotic cell cycle.
Article Abstract
Orderly execution of two critical events during the cell cycle--DNA replication and chromosome segregation--ensures the stable transmission of genetic materials. The cohesin complex physically connects sister chromatids during DNA replication in a process termed sister chromatid cohesion. Timely establishment and dissolution of sister chromatid cohesion is a prerequisite for accurate chromosome segregation, and is tight regulated by the cell cycle machinery and cohesin-associated proteins. In this review, we discuss recent progress in the molecular understanding of sister chromatid cohesion during the mitotic cell cycle.
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| http://dx.doi.org/10.1007/s11427-015-4956-7 | DOI Listing |
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