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Ceasing or gradually reducing incubator humidity after 7 days for extremely preterm infants: a randomised clinical trial.
Eur J Pediatr
December 2024
Grantley Stable Neonatal Unit (GSNU), Royal Brisbane and Women's Hospital, Herston, Brisbane, QLD, Australia.
Unlabelled: The purpose of this study is to compare the effects of two different ways of stopping incubator humidification on episodes of hypothermia, hyperthermia, hyponatraemia, hypernatraemia, or skin injury. The design is a single site, two-armed, parallel, randomised, clinical trial conducted between April 2019 and March 2022. The setting was a quaternary referral and teaching hospital in Queensland, Australia.
View Article and Find Full Text PDFAdipsic arginine vasopressin deficiency: challenges in managing the intricate interplay of adipsia with polyuria.
BMJ Case Rep
October 2024
Endocrinology and Metabolism, All India Institute of Medical Science, Bhopal, Madhya Pradesh, India
Article Synopsis
- Adipsic arginine vasopressin deficiency (AAVP-D) occurs due to hypothalamic dysfunction, often linked to conditions like craniopharyngiomas, which makes management difficult since key mechanisms for regulating plasma osmolality are impaired.
- Patients with AAVP-D can suffer from severe dehydration and elevated sodium levels (hypernatraemia), leading to frequent emergency visits despite treatment with desmopressin, an arginine vasopressin analogue.
- A case study highlights the successful management of AAVP-D through careful water intake regulation and desmopressin administration, resulting in stable serum sodium levels (140-150 mmol/L) and no emergency visits over a three-month period.
Extreme hypernatremia after a laparoscopic hysterectomy and bilateral salpingo-oophorectomy: a case report and literature review.
Front Surg
October 2024
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- * A case study details an unusual instance of NDI in a 50-year-old Chinese woman who developed symptoms after cervical cancer surgery, leading to a diagnosis through various tests and genetic analysis revealing a specific mutation.
- * The patient improved significantly after a low-sodium diet and medication, highlighting the necessity of specialized tests to accurately diagnose and manage NDI, even in older females, where it's less common.
Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol.
J Perinatol
October 2024
Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa, IA, USA.
Article Synopsis
- * It analyzed data from two groups of infants before and after the protocol's implementation, showing significant growth improvements (body weight and head circumference) in those born at 26-29 weeks.
- * Results indicated that the protocol reduced the need for mechanical ventilation but did not increase the risk of health issues like hypertension or infections in extremely preterm infants.
Effects of Acute Hypernatremia on the Electrophysiology of Single Human Ventricular Cardiomyocytes: An Study.
Rev Cardiovasc Med
June 2024
Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Background: Clinical and experimental data on the cardiac effects of acute hypernatremia are scarce and inconsistent. We aimed to determine and understand the effects of different levels of acute hypernatremia on the human ventricular action potential.
Methods: We performed computer simulations using two different, very comprehensive models of the electrical activity of a single human ventricular cardiomyocyte, , the Tomek-Rodriguez model following the O'Hara-Rudy dynamic (ORd) model and the Bartolucci-Passini-Severi model as published in 2020 (known as the ToR-ORd and BPS2020 models, respectively).
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