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Monoclonal Gammopathy of Thrombotic Significance.
Cancers (Basel)
January 2023
Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 15772 Athens, Greece.
The current review provides an overview of the thrombotic risk observed in patients with MG who do not otherwise require treatment. We discuss clinical and biomarker studies that highlight the heterogenous hemostatic profile observed in these patients and how knowledge has evolved over the past 20 years. Biomarker studies suggest shared biologic features between multiple myeloma and monoclonal gammopathy of undetermined significance (MGUS), which involves both hypercoagulability and platelet activation.
View Article and Find Full Text PDFCryofibrinogenemia and risk of cancer in cryoglobulinemic patients without vasculitis criteria.
Eur J Intern Med
March 2016
Department of Internal Medicine, Toulouse University Hospital, Toulouse, France; Institut National de la Recherche Medicale (INSERM) U858, Toulouse, France; Toulouse University, Toulouse, France.
Cryofibrinogenemia After a Liver Transplant: First Reported Case Posttransplant and a Case-Based Review of the Nontransplant Literature.
Exp Clin Transplant
June 2015
From the Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Cryofibrinogenemia is a rare disorder in which plasma, not serum, forms a cryoprecipitate. Patients with cryofibrinogenemia may be asymptomatic, or they may have painful ulcers, purpura, livedo reticularis, Raynaud phenomenon, perniosis of the extremities, thrombosis, and arthralgia. Cryofibrinogenemia may be primary or secondary to an underlying disorder such as connective tissue disease, malignancy, infection, drugs, or thromboembolic disease.
View Article and Find Full Text PDFA case of recurrent severe pre-eclampsia associated with essential cryofibrinogenaemia.
Obstet Med
September 2013
Renal Unit.
Essential cryofibrinogenaemia is a rare disorder characterized by cryofibrinogens without cryoglobulins. Connective tissue disorders and thrombophilia are known to increase risk of pre-eclampsia, but pre-eclampsia has not previously been reported in association with cryofibrinogenaemia. We report the case of a 32-year-old woman with recurrent severe pre-eclampsia diagnosed with essential cryofibrinogenaemia.
View Article and Find Full Text PDFCryofibrinogenemia.
J Clin Rheumatol
April 2013
Departments of Internal Medicine, CHU Toulouse, France.
Cryofibrinogenemia is a cryoprotein that was first identified in 1955 by Korst and Kratochvil. Unlike cryoglobulin, the precipitate forms only in plasma and not in the serum. The presence of cryofibrinogen in plasma can be asymptomatic.
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