Relationship between Helicobacter pylori infection and metabolic syndrome.

Background/aims: To investigate the prevalence of metabolic syndrome (MS) and its components in patients with Helicobacter pylori that was detected using histopathological diagnostic methods.

Materials And Methods: The study included 200 patients who presented with dyspeptic complaints and had indication for endoscopy. H. pylori-positive [HP (+)] and H. pylori-negative [HP (-)] patients were compared in terms of MS and its components.

Results: The prevalence of H. pylori in general patient population is 49.5%. When patients were examined using a diagnostic criteria of MS, MS was present in 78 patients (78.8%) in the HP (+) (n=99) group and in 22 patients (21.8%) in the HP (-) (n=101) group (p<0.01). Logistic regression analysis revealed that H. pylori infection enhances the risk of developing MS by approximately 3.6 times (Relative Risk - (RR)=3.617, 95% CI: 2.465-5.307, p<0.001). With regard to the MS criteria, mean systolic-diastolic blood pressures and body mass index were significantly higher in HP (+) individuals than in HP (-) individuals. Furthermore, fasting plasma glucose, insulin and homeostatic model assessment-insulin resistance, very low-density lipoproteins, and triglyceride levels were also higher in the HP (+) group, whereas high-density lipoproteins levels were lower.

Conclusion: H. pylori infection is a risk factor for MS. H. pylori leads to insulin resistance by developing chronic inflammation and accordingly facilitates the development of MS.