AI Article Synopsis
- The study explores the relationship between genetic risk factors for bipolar disorder (BD) and brain arousal regulation as measured by EEG, based on the vigilance regulation model.
- Using a sample from the Leipzig Health Care Study, researchers analyzed EEG data from 540 participants, focusing on specific BD risk alleles to see if they influenced brain arousal patterns.
- While some initial findings suggested connections between certain genetic variants and brain arousal, these results could not be replicated, indicating that more research is needed to understand the genetics behind brain arousal regulation in BD.
Article Abstract
Objectives: Recent genome-wide association studies identified a number of chromosomal risk loci for bipolar disorder (BD, 'manic-depressive illness'). According to the vigilance regulation model, the regulation of brain arousal (referred to as 'vigilance') when assessed via EEG is an emerging biomarker linked to the pathogenesis of manic and depressive episodes. On this basis, the present study aimed to assess whether carriers of BD risk alleles differ in brain arousal regulation.
Methods: Healthy participants of the population-based Leipzig Health Care Study (LIFE) underwent a 20-min eyes-closed resting EEG paradigm. Brain arousal was assessed applying the computer-based Vigilance Algorithm Leipzig (VIGALL). The primary sample (n = 540) was genotyped for ten of the most reliable BD risk variants, of which two qualified for replication (n = 509).
Results: Primary sample analyses revealed Bonferroni-adjusted significance for rs1006737 in CACNA1C (encoding a calcium channel subunit), with risk allele carriers exhibiting relatively steep brain arousal declines. Further, carriers of two risk alleles of rs472913 at 1p32.1 showed generally lower brain arousal levels for the duration of the resting paradigm. However, both associations failed replication.
Conclusion: Although our initial findings are in line with the vigilance regulation model and convincing in view of the previously reported notable role of ion channelopathies in BD, our results do not provide consistent evidence for a link between BD risk variants and brain arousal regulation. Several between-sample differences may account for this inconsistency. The molecular genetics of brain arousal regulation remain to be clarified.
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| http://dx.doi.org/10.1159/000437438 | DOI Listing |
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