Statins are a widely used group of drugs which can lower cholesterol levels. Recently, there has been emerging evidence that statins may decrease the formation of cholesterol gallstones and several studies have reported invert association between symptomatic cholesterol gallstones and statin use. Subsequent evidence for decrease in gallstone-associated complications among statin users have not been clearly described. In this review we summarize current evidence for the association between statin use and the risk of gallstone-associated complications.
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Imaging of gallstones and complications.
Curr Probl Diagn Radiol
December 2024
Department of Radiology, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ, 85259, USA. Electronic address:
Gallbladder pathologies caused by gallstones are commonly encountered in clinical practice, making accurate diagnosis critical for effective patient management. Radiologists play a key role in differentiating these conditions through imaging interpretation, ensuring that appropriate treatment is initiated. The imaging features of gallstone associated diseases are classified into various categories, such as inflammatory conditions, benign lesions, malignant tumors, and associated complications.
View Article and Find Full Text PDFAssociation between HNF4A rs1800961 polymorphisms and gallstones in a Taiwanese population.
J Gastroenterol Hepatol
February 2024
Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Background And Aim: A large genetic effect of a novel gallstone-associated genetic variant, the hepatocyte nuclear factor 4α (HNF4A) rs1800961 polymorphism, has been identified through recent genome-wide association studies. However, this effect has not been validated in Asian populations. We investigated the association between the rs1800961 variant and gallstones among a Taiwanese population.
View Article and Find Full Text PDFJourney of a stone-thirty years on.
J Surg Case Rep
February 2023
Acute Care and Trauma Surgery, Gold Coast Health & Hospital Services, Gold Coast QLD, Australia.
Laparoscopic cholecystectomy is the gold standard surgical treatment of gallstone disease and a commonly performed procedure in general surgery. Retained gallstones from intraoperative spillage remain largely asymptomatic and complications are rare. Peak incidence of presentation occurs within a year; however, it is important to recognize retained gallstones as a differential for acute presentations even many years postoperatively.
View Article and Find Full Text PDFTreatment of asymptomatic gallstones in children with hereditary spherocytosis requiring splenectomy.
J Pediatr Surg
April 2023
Department of General Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No.56 Nanlishi St, Beijing 100045, China. Electronic address:
Background: Gallstones are common in hereditary spherocytosis (HS) and other chronic hemolytic diseases, with most affected patients being asymptomatic. Whether and how asymptomatic gallstones should be treated is controversial.
Methods: We conducted a retrospective cohort study of pediatric patients with HS and asymptomatic gallstones to compare the clinical outcomes between the observation group (followed up with gallstones in situ) and the intervention group (cholecystectomy or cholecystolithotomy).
Commentary on "Gallstone associated celiac trunk thromboembolisms complicated with splenic infarction: A case report''.
World J Clin Cases
November 2022
Department of Radiology, Erzincan University Medicine Faculty, Erzincan 24100, Turkey.
The present letter to the editor is related to the study titled "Gallstone associated celiac trunk thromboembolisms complicated with splenic infarction: A case report''. Although gallstones are relatively common diseases, its association with thromboembolism is not fully understood. We aim to emphasize the potential mechanism of this relationship in this letter.
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