Factoring the brain signatures of anesthesia concentration and level of arousal across individuals.

Neuroimage Clin

Universidad Torcuato di Tella, Almirante Juan Saenz Valiente 1010, Buenos Aires C1428BIJ, Argentina.

Published: July 2016

Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants' level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588413PMC
http://dx.doi.org/10.1016/j.nicl.2015.08.013DOI Listing

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