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Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw. | LitMetric

Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw.

Ther Clin Risk Manag

Department of Cranio-facial Trauma and Orthognathic Surgery Laboratory of Military Stomatology, School of Stomatology, The Fourth Military Medical University, Shaanxi Key Laboratory of Stomatology, Xi'an, People's Republic of China.

Published: October 2015

Hydrogen, a therapeutic medical gas, can exert antioxidant activity via selectively reducing cytotoxic reactive oxygen species such as hydroxyl radicals. Hydrogen-rich saline is an alternative form of molecular hydrogen that has been widely used in many studies, including metabolic syndrome, cerebral, hepatic, myocardial ischemia/reperfusion, and liver injuries with obstructive jaundice, with beneficial results. Osteoradionecrosis of the jaw is a serious complication following radiotherapy for head and neck cancers. It has long been known that most radiation-induced symptoms are caused by free radicals generated by radiolysis of H2O, and the hydroxyl radical is the most reactive of these. Reducing the hydroxyl radical can distinctly improve the protection of cells from radiation damage. We hypothesized that hydrogen-rich saline might be an effective and specific method of managing and preventing osteoradionecrosis of the jaw.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610769PMC
http://dx.doi.org/10.2147/TCRM.S90770DOI Listing

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