AI Article Synopsis
- The study aimed to explore the link between certain genetic variations (polymorphisms) in the APE1 gene and the risk of noise-induced hearing loss (NIHL) in a Chinese population.
- Researchers compared genetic data from 613 workers with NIHL and 613 workers with normal hearing using a specific testing method.
- The findings indicated that the APE1 -656 TT genotype significantly increased the risk of NIHL, especially in individuals with two specific risk genotypes, suggesting a genetic contribution to susceptibility to this condition.
Article Abstract
Objective: To investigate whether the apurinic/apyrimidinic endonuclease 1 (APE1) 1349 T>G and -656 T>G polymorphisms were associated with the risk of noise-induced hearing loss (NIHL) in a Chinese population.
Methods: The two APE1 polymorphisms were analyzed among 613 NIHL workers and 613 normal hearing workers using the minor groove binder TaqMan probe assay.
Results: We found that the APE1 -656 TT genotype was associated with a increased risk of NIHL [adjusted odds ratio (OR) 1.46, 95% confidence interval (CI) 1.05-2.06]. This increased risk was more pronounced in the stratification analysis. Furthermore, we found that subjects with two risk genotypes (hOGG1 Cys/Cys, APE1 -656 TT) had a significantly increased risk of NIHL (adjusted OR 1.91, 95% CI 1.27-2.88).
Conclusion: Our study identified that the APE1 -656 T>G polymorphism may contribute to the susceptibility of NIHL.
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| http://dx.doi.org/10.1007/s00420-015-1100-8 | DOI Listing |
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