Intraductal papillary mucinous neoplasm (IPMN) of the pancreas and intraductal papillary neoplasm of the bile duct (IPNB) are considered as counterparts of each other, and it is suggested that these two entities have similar molecular alteration pathways. However, the occurrence of IPMN of the pancreas and IPNB in the same patient is rare. We report a surgical case of a 69-year-old woman who developed invasive IPMN of the pancreas and underwent pancreatectomy, 6 months after hepatic resection of invasive IPNB. Molecular analysis revealed GNAS/KRAS mutation in both invasive IPMN of the pancreas and IPNB. This is believed to be the first case report investigating GNAS/KRAS mutational status in both IPMN of the pancreas and IPNB developing in the same patient, and these two entities may show similar molecular alternations.
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| http://dx.doi.org/10.1016/j.pan.2015.09.013 | DOI Listing |
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Article Synopsis
- The study assesses the risk associated with sub-centimeter Side-Branch Intraductal Papillary Mucinous Neoplasms (SB-IPMN) to inform a surveillance strategy.
- Sub-centimeter SB-IPMNs show a lower rate of clinically relevant progression compared to larger cysts, although they can still develop high-risk pathologies over time.
- The findings suggest that size growth alone is not a reliable indicator of malignant potential, emphasizing the need for careful monitoring regardless of cyst size.
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