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Towards constructing a generalized structural 3D breathing human lung model based on experimental volumes, pressures, and strains.
PLoS Comput Biol
January 2025
Department of Mechanical Engineering, University of California Riverside, Riverside, California, United States of America.
Respiratory diseases represent a significant healthcare burden, as evidenced by the devastating impact of COVID-19. Biophysical models offer the possibility to anticipate system behavior and provide insights into physiological functions, advancements which are comparatively and notably nascent when it comes to pulmonary mechanics research. In this context, an Inverse Finite Element Analysis (IFEA) pipeline is developed to construct the first continuously ventilated three-dimensional structurally representative pulmonary model informed by both organ- and tissue-level breathing experiments from a cadaveric human lung.
View Article and Find Full Text PDFImplantable and transcutaneous photobiomodulation promote neuroregeneration and recovery of lost function after spinal cord injury.
Bioeng Transl Med
November 2024
Neuroscience and Ophthalmology Institute of Inflammation and Ageing, University of Birmingham Birmingham UK.
Spinal cord injury (SCI) is a cause of profound and irreversible damage, with no effective therapy to promote functional recovery. Photobiomodulation (PBM) may provide a viable therapeutic approach using red or near-infrared light to promote recovery after SCI by mitigating neuroinflammation and preventing neuronal apoptosis. Our current study aimed to optimize PBM dose regimens and develop and validate the efficacy of an invasive PBM delivery paradigm for SCI.
View Article and Find Full Text PDFProfiles, tissue and microbial integrity of cadavers used in medical faculties in South-western Uganda: implication in anatomical education.
Anat Cell Biol
October 2024
Department of Human Anatomy, Kampala International University, Western Campus, Bushenyi, Uganda.
Cadaveric dissection has remained an integral part of anatomical education globally; hence, the profiles of cadavers, their gross tissue and microbial integrity has great implication in anatomical education. This study determined the profiles, gross tissue and microbial integrity of cadavers used in South-western Uganda (SWU) medical schools. A cross-sectional study was carried out for three months in anatomy and microbiology laboratories of SWU medical teaching institutions.
View Article and Find Full Text PDFSeasonal mouse cadaver microbial study: rupture time and postmortem interval estimation model construction.
PeerJ
September 2024
Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.
The estimation of postmortem interval (PMI) has long been a focal point in the field of forensic science. Following the death of an organism, microorganisms exhibit a clock-like proliferation pattern during the course of cadaver decomposition, forming the foundation for utilizing microbiology in PMI estimation. The establishment of PMI estimation models based on datasets from different seasons is of great practical significance.
View Article and Find Full Text PDFTransungual Penetration and Antifungal Activity of Prescription and Over-the-Counter Topical Antifungals: Ex Vivo Comparison.
Dermatol Ther (Heidelb)
September 2024
Case Western Reserve University, Cleveland, OH, USA.
Introduction: Topical antifungals for toenail onychomycosis must penetrate the nail to deliver an inhibitory concentration of free drug to the site of infection. In two ex vivo experiments, we tested the ability of topical antifungals to inhibit growth of Trichophyton rubrum and Trichophyton mentagrophytes, the most common causative fungi in toenail onychomycosis.
Methods: Seven topical antifungals were tested: three U.
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