Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631204 | PMC |
| http://dx.doi.org/10.15252/msb.156513 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Continuous carbon source supply is essential for high rifamycin productivity of in nitrate-stimulated fermentation revealed by a metabolomic study.
Acta Biochim Biophys Sin (Shanghai)
January 2025
CAS Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences (CAS), Shanghai 200032, China.
U32 is an industrial strain capable of producing therapeutically useful rifamycin SV. In early days of fermentation studies, nitrate was found to increase the yield of rifamycin along with globally, affecting both carbon and nitrogen metabolism in favor of antibiotic biosynthesis; thus, the (NSE) hypothesis was proposed. Although GlnR is likely the master regulator of the pleotropic effect of NSE, the global metabolism affected by NSE has never been systematically examined.
View Article and Find Full Text PDFNovel inhibitors of the (VIBVN) NAT protein identified through pharmacophore modeling.
Sci Rep
January 2025
Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ministry of Education, Ocean University of China, Qingdao, 266071, China.
Arylamine N-acetyltransferases (NATs, E.C. 2.
View Article and Find Full Text PDFUnveiling the guardians of the genome: The dynamic role of histones in DNA organization and disease.
Adv Protein Chem Struct Biol
January 2025
CsrDD Lab, Department of Microbiology, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune, India. Electronic address:
Histones are positively charged proteins found in the chromatin of eukaryotic cells. They regulate gene expression and are required for the organization and packaging of DNA within the nucleus. Histones are extremely conserved, allowing for transcription, replication, and repair.
View Article and Find Full Text PDFDeuterated Nanopolymers for Renal and Lymphatic Imaging via Quantitative Deuterium MRI.
Nano Lett
January 2025
NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany.
Deuterium (H) MRI is an emerging tool for noninvasive imaging. We explore the integration of H MRI with deuterated multifunctional nanopolymers for deuterated particle imaging (DPI). To this end, amine-terminated G5-polyamidoamine (PAMAM) dendrimers were labeled with deuterated acetyl surface groups, leading to highly H-loaded bioparticles, making them ideal for imaging studies.
View Article and Find Full Text PDFAltered cytoskeleton dynamics in patient-derived iPSC-based model of PCDH19 clustering epilepsy.
Front Cell Dev Biol
January 2025
Molecular Genetics and Functional Genomics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Protocadherin 19 (PCDH19) is an adhesion molecule involved in cell-cell interaction whose mutations cause a drug-resistant form of epilepsy, named PCDH19-Clustering Epilepsy (PCDH19-CE, MIM 300088). The mechanism by which altered PCDH19 function drive pathogenesis is not yet fully understood. Our previous work showed that PCDH19 dysfunction is associated with altered orientation of the mitotic spindle and accelerated neurogenesis, suggesting a contribution of altered cytoskeleton organization in PCDH19-CE pathogenesis in the control of cell division and differentiation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!