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Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043-02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial.
Lancet Microbe
December 2024
Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Germany; German Center for Infection Research, Munich Partner Site, Munich, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection, and Pandemic Research, Munich, Germany; Unit Global Health, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Electronic address:
Background: The broad use of bedaquiline and pretomanid as the mainstay of new regimens to combat tuberculosis is a risk due to increasing bedaquiline resistance. We aimed to assess the safety, bactericidal activity, and pharmacokinetics of BTZ-043, a first-in-class DprE1 inhibitor with strong bactericidal activity in murine models.
Methods: This open-label, dose-expansion, randomised, controlled, phase 1b/2a trial was conducted in two specialised tuberculosis sites in Cape Town, South Africa.
The efficacy and feasibility of lifestyle interventions on modifiable cardiovascular disease risk factors among people with inflammatory bowel disease.
Proc Nutr Soc
January 2025
University of Otago, Dunedin, New Zealand.
This review aims to highlight the relative importance of cardiovascular disease (CVD) lifestyle-associated risk factors among individuals with inflammatory bowel disease (IBD) and examine the effectiveness of lifestyle interventions to improve these CVD risk factors. Adults with IBD are at higher risk of CVD due to systemic and gut inflammation. Besides that, tobacco smoking, dyslipidaemia, hypertension, obesity, physical inactivity, and poor diet can also increase CVD risk.
View Article and Find Full Text PDFPhysiological effects of combined breathing and physical training in middle-aged and older adults.
J Phys Ther Sci
January 2025
Center for Frontier Medical Engineering, Chiba University, Japan.
[Purpose] The safety and physiological effects of combined training with breathing resistance and sustained physical exertion in middle-aged and older adults remain unclear. This pilot study investigated the safety and physiological benefits of this training method in older adults. [Participants and Methods] Participants aged 55-75 without respiratory, circulatory, or metabolic diseases were randomly divided into two groups: a combined breathing and physical training group and a control group.
View Article and Find Full Text PDFUse of high flow nasal cannula in critical burn patient during deep sedation in enzymatic bromelain debridement (nexobrid): a single center brief report.
Ann Burns Fire Disasters
December 2024
Burn Intensive Care Unit, Poison Control Center, Cardarelli Hospital, Naples, Italy.
The use of new oxygen supports associated to non-invasive respiratory strategies is well-established in clinical practice, especially after its extensive application in the management of Covid-19 respiratory failure. The use of high flow nasal cannula (HFNC) in patients undergoing procedural sedation and analgesia (PSA) is dramatically increasing. Enzymatic debridement in critical burn patients is a painful treatment that requires an optimal burn pain control protocol as well as a deep sedation for the entire duration of the procedure.
View Article and Find Full Text PDFEstablishing Minimally Invasive Cardiac Surgery in a Developing Country: A Five-Year Experience at Hayatabad Medical Complex, Pakistan.
Cureus
November 2024
Cardiovascular Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK.
Background The adoption of minimally invasive cardiac surgery (MICS) has increased over the past 25 to 30 years, driven by advancements in technology and a growing understanding of its benefits. This study evaluates the outcomes of 144 elective MICS procedures performed between January 2019 and September 2024. Methods Patients underwent various surgical approaches, including upper mini-sternotomy, mini-thoracotomy, and sub-xiphoid access.
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