Background: Analysis of gait features provides important information during the treatment of neurological disorders, including Parkinson's disease. It is also used to observe the effects of medication and rehabilitation. The methodology presented in this paper enables the detection of selected gait attributes by Microsoft (MS) Kinect image and depth sensors to track movements in three-dimensional space.
Methods: The experimental part of the paper is devoted to the study of three sets of individuals: 18 patients with Parkinson's disease, 18 healthy aged-matched individuals, and 15 students. The methodological part of the paper includes the use of digital signal-processing methods for rejecting gross data-acquisition errors, segmenting video frames, and extracting gait features. The proposed algorithm describes methods for estimating the leg length, normalised average stride length (SL), and gait velocity (GV) of the individuals in the given sets using MS Kinect data.
Results: The main objective of this work involves the recognition of selected gait disorders in both the clinical and everyday settings. The results obtained include an evaluation of leg lengths, with a mean difference of 0.004 m in the complete set of 51 individuals studied, and of the gait features of patients with Parkinson's disease (SL: 0.38 m, GV: 0.61 m/s) and an age-matched reference set (SL: 0.54 m, GV: 0.81 m/s). Combining both features allowed for the use of neural networks to classify and evaluate the selectivity, specificity, and accuracy. The achieved accuracy was 97.2 %, which suggests the potential use of MS Kinect image and depth sensors for these applications.
Conclusions: Discussion points include the possibility of using the MS Kinect sensors as inexpensive replacements for complex multi-camera systems and treadmill walking in gait-feature detection for the recognition of selected gait disorders.
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http://dx.doi.org/10.1186/s12938-015-0092-7 | DOI Listing |
Eur Geriatr Med
January 2025
School of Medicine, Trinity College Dublin, Dublin, Ireland.
Purpose: As the global population of older adults rises, the United Nations Decade of Healthy Ageing (2021-2030) advocates for disease prevention, management, and enhancing overall wellbeing in older adults. We reviewed the MEDLINE literature under the MeSH term "music therapy" (MT), for its role in promoting healthy ageing.
Methods: A systematic search of the MEDLINE biomedical database (Ovid) was conducted using "MT" and "Ageing" as keywords, retrieving relevant full-text studies in English.
NPJ Digit Med
January 2025
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Adaptive deep brain stimulation (DBS) provides individualized therapy for people with Parkinson's disease (PWP) by adjusting the stimulation in real-time using neural signals that reflect their motor state. Current algorithms, however, utilize condensed and manually selected neural features which may result in a less robust and biased therapy. In this study, we propose Neural-to-Gait Neural network (N2GNet), a novel deep learning-based regression model capable of tracking real-time gait performance from subthalamic nucleus local field potentials (STN LFPs).
View Article and Find Full Text PDFNPJ Parkinsons Dis
January 2025
Department of Life Sciences and Medicine (DLSM), University of Luxembourg, Belvaux, Luxembourg.
Loss-of-function mutations in PARK7, encoding for DJ-1, can lead to early onset Parkinson's disease (PD). In mice, Park7 deletion leads to dopaminergic deficits during aging, and increased sensitivity to oxidative stress. However, the severity of the reported phenotypes varies.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Distinguishing between Parkinson's disease (PD) and essential tremor (ET) can be challenging sometimes. Although positron emission tomography can confirm PD diagnosis, its application is limited by high cost and exposure to radioactive isotopes. Patients with PD exhibit loss of the dorsal nigral hyperintensity on brain magnetic resonance imaging (MRI).
View Article and Find Full Text PDFNPJ Parkinsons Dis
January 2025
Department of Molecular Pathology, IRCCS Neuromed, Pozzilli, Italy.
Metabotropic glutamate (mGlu) receptors are candidate drug targets for therapeutic intervention in Parkinson's disease (PD). Here we focused on mGlu3, a receptor subtype involved in synaptic regulation and neuroinflammation. mGlu3 mice showed an enhanced nigro-striatal damage and microglial activation in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
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