Personalizing the release profiles of drugs is important for different people with different medical and biological conditions. A technically simple and low-cost method to fabricate fully customizable tablets that can deliver drugs with any type of release profile is described. The customization is intuitively straightforward: the desired profile can simply be "drawn" and printed by a 3D printer.
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http://dx.doi.org/10.1002/adma.201504122 | DOI Listing |
Genome Biol
January 2025
Cancer Centre, University of Macau, Taipa, Macau SAR.
Biological data visualization is challenged by the growing complexity of datasets. Traditional single-data plots or simple juxtapositions often fail to fully capture dataset intricacies and interrelations. To address this, we introduce "cross-layout," a novel visualization paradigm that integrates multiple plot types in a cross-like structure, with a central main plot surrounded by secondary plots for enhanced contextualization and interrelation insights.
View Article and Find Full Text PDFJ Phys Condens Matter
December 2024
Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India.
Solution grown quantum dots (QD) are promising materials for photonic quantum science. These materials are strongly confined and further offer advantages in terms of customizability and scalability. In this review we describe the applications of these materials towards quantum science particularly as single photon emitters.
View Article and Find Full Text PDFPlast Reconstr Surg Glob Open
December 2024
Infinitebook, AIRV-Associação Empresarial da Região Viseu, Viseu, Portugal.
Background: Over the past decade, plastic and reconstructive procedures have notably increased, driven by greater accessibility and aesthetic preferences. Despite surgeons' efforts, patient satisfaction faces challenges due to unrealistic expectations rooted in inadequate knowledge. Preoperative consultations present an opportune moment to address this issue.
View Article and Find Full Text PDFRev Sci Instrum
December 2024
Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
The development of systems to measure and optimize emerging energetic material performance is critical for Chemical Warfare Agent (CWA) defeat. In order to assess composite metal powder efficacy on CWA simulant defeat, this study documents a combination of two spectroscopic systems designed to monitor the decomposition of a CWA simulant and temperature rises due to combusting metal powders simultaneously. The first system is a custom benchtop Polygonal Rotating Mirror Infrared Spectrometer (PRiMIRS) incorporating a fully customizable sample cell to observe the decomposition of Diisopropyl Methyl Phosphonate (DIMP) as it interacts with combusting composite metal particles.
View Article and Find Full Text PDFSmall
December 2024
Chair of Macromolecular Chemistry, Institute of Functional Materials and Biofabrication, Faculty of Chemistry and Pharmacy, Julius -Maximilians-Universität-Würzburg, Röntgenring 11, 97070, Würzburg, Germany.
Cationic, core-crosslinked nanogel particles are prepared from synthetic biodegradable materials. These fully hydrophilic nanogels offer superior customizability compared to common lipid nanoparticles, thereby circumventing intrinsic immune stimulatory properties. Electrostatic loading allows for complexation of nucleic acids including the immune stimulatory Toll-like receptor 9 (TLR9) agonistCpG-ODN (cytidine-phosphate-guanosine oligodeoxynucleotide).
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