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Successful Treatment of Severe Ectopic ACTH-Dependent Cushing Syndrome Complicated by Hypocalcemia With Osilodrostat.
JCEM Case Rep
February 2025
Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Cushing syndrome due to ectopic adrenocorticotropic hormone (ACTH) secretion (EAS) is rare and may progress rapidly, making treatment very challenging. We report a 27-year-old woman with metastatic neuroendocrine tumor (NET) who presented with sudden onset and rapidly progressing fatigue, muscle weakness, and weight gain. Laboratory findings confirmed severe EAS with new onset hypocalcemia, hypokalemia, and hyperglycemia.
View Article and Find Full Text PDFSevere sepsis is cognate with life threatening multi-organ dysfunction. There is a disturbance in endocrine functions with alterations in several hormonal pathways. It has frequently been linked with dysfunction in the hypothalamic pituitary-adrenal axis (HPA).
View Article and Find Full Text PDFMother-infant stress contagion? Effects of an acute maternal stressor on maternal caregiving behavior and infant cortisol and crying.
J Child Psychol Psychiatry
January 2025
Department of Cognitive Neuroscience, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.
Background: Postpartum maternal distress has been associated with adverse infant outcomes. A potential pathway of how maternal distress affects infant outcomes could be alterations in maternal caregiving behavior. However, the associations between maternal distress, caregiving behavior, and infant outcomes have never been tested in a controlled experiment.
View Article and Find Full Text PDFStress, lipid profile and inflammatory responses to flunixin meglumine administration in surgical and non-surgical castration in donkeys.
Vet Anim Sci
March 2025
Department of Clinical Pathology and Internal Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Donkeys are in the Equidae family but have several differences from horses. There are many studies on the pathophysiology of pain and its clinical signs in horses, but data are limited for donkeys. Therefore, the present study aimed to investigate biochemical effects of flunixin meglumine in donkeys subjected to pain induced by bloodless and surgical castration.
View Article and Find Full Text PDFAge-associated alterations in immune and inflammatory responses in captive olive baboons ().
Front Aging
January 2025
The University of Texas MD Anderson Cancer Center Bastrop, Department of Comparative Medicine TX, Bastrop, TX, United States.
Introduction: Advanced age is a primary risk factor for many chronic diseases and conditions; however, age-related immune dysregulation is not well understood. Animal models, particularly those that resemble human age-related physiological changes, are needed to better understand immunosenescence and to improve health outcomes. Here, we explore the utility of the olive baboon (Papio anubis) in studying age-related changes to the immune system and understanding mechanisms of immunosenescence.
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