AI Article Synopsis
- The study compares the pharmacokinetics of different curcumin formulations in SD rats, focusing on the hydroxypropyl-β-cyclodextrin phospholipid complex.
- Blood samples were taken after oral administration to measure drug concentration using HPLC, at a dosage of 50 mg/kg.
- Results showed that the hydroxypropyl-β-cyclodextrin phospholipid complex demonstrated significantly greater absorption and bioavailability compared to the other formulations.
Article Abstract
Objective: To compare the in vivo pharmacokinetics of curcumin hydroxypropyl-β-cyclodextrin phospholipid complex, curcumin hydroxypropyl-β-cyclodextrin and curcumin phospholipid complex, and to discuss the advantage of hydroxypropyl-β-cyclodextrin phospholipid complex as carrier.
Methods: Drawing blood after SD rats were oral administered with the above preparations and free drug at 50 mg/kg( corresponding to curcumin) , and the blood concentration were determined by HPLC.
Results: The AUC0-∞ of curcumin hydroxypropyl-β-cyclodextrin phospholipid complex was(1 126. 20 ± 323. 24) g/(L . h), which was 5. 89, 1. 49 and 1. 17 times as curcumin (191. 08 ± 43. 27) µg/( L . h), curcumin phospholipid complex(754. 93 ± 55. 33) µg/(L . h), curcumin hydroxypropyl-β- cyclodextrin(961. 21 ± 253. 65) µg/(L . h).
Conclusion: The curcumin hydroxypropyl-β-cyclodextrin phospholipid complex has a better absorption property than curcumin phospholipid complex and curcumin hydroxypropyl-β-cyclodextrin, which is more beneficial to improve the bioavailability.
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